The relationship between abdominal fat, glucose-regulated protein 78, and endometrial cancer

Main Article Content

Razvan Ciortea
Mihai Capilna
Andrei Mihai Malutan
Lenuta Maria Angheluta
Carmen Elena Bucuri
Dan Mihu

Keywords

GRP78, abdominal fat, endometrial cancer GRP78, grasso addominale, cancro dell’endometrio

Abstract

Background and aim: The adipocyte is the central element that integrates multiple metabolic and endocrine signals. This cell is the source for a multitude of bioactive peptides that play an essential role in endometrial cancer pathogenesis. The association of obesity with endometrial cancer is supported by Glucose-regulated protein 78 (GRP78), a marker of the stress endoplasmic reticulum (ER). GRP78 has an important anti-apoptotic role. Recent studies have demonstrated that GRP 78 plays an important role in the development, progression and tumor chemoresistance. The study aimed to identify a correlation between abdominal obesity, plasma GRP 78 level an d endometrial cancer. Methods: Two groups of patients were included in the study: group I – 44 patients diagnosed with endometrial cancer, group II – 44 patients without gynecological pathology or inflammatory disorders. After the performance of clinical examination and anthropometric measurements, abdominal fat was determined by dual X-ray absorptiometry and plasma GRP 78 level was measured. Results: Plasmatic level of GRP78 was significant higher in patients with endometrial cancer compared to the control group. Abdominal fat is in a positive linear correlation with the plasma GRP78 level (p<0.0001). Conclusions: The measurement GRP78 level associated with the determination of abdominal fat can be an useful predictor factor for endometrial cancer.
Abstract 94 | PDF Downloads 21