Oxaliplatin-based second-line chemotherapy in neuroendocrine carcinomas. A case series and review of the literature

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Salvatore Galdy
Luigi Funicelli
Andrea Luciani
Dario Giuffrida
Francesca Spada
Chiara Alessandra Cella
Sabina Murgioni
Anna Maria Frezza
Nicola Fazio

Keywords

gastroenteropancreatic, neuroendocrine carcinomas, oxaliplatin, second-line chemotherapy

Abstract

Patients with metastatic gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) are generally treated with a first-line chemotherapy including cisplatin and etoposide, in the absence of randomized trials. No specific second-line regimen has been reported. According to some retrospective data, platinum rechallenge could be considered in GEP-NECs. However, in view of the considerable platinoid toxicity profile, it would be advisable to consider an analogue thereof in order to minimize cumulative toxicity. We present the clinical history of three metastatic GEP-NEC patients who underwent oxaliplatin-based second-line chemotherapy after progression on platinum-based first-line chemotherapy.
 

 

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