Circulating resistin in ulcerative colitis, relation with anthropometric, body composition and inflammatory parameters

Main Article Content

Nasim Abedimanesh
Behrooz Motlagh
Saeed Abedimanesh
Alireza Ostadrahimi
Mohammad Hossein Somi
Mohammad Asghari Jafarabadi
Mahin Rezazadeh

Keywords

resistin, body composition, inflammation, anthropometry

Abstract

Background: Chronic inflammation, altered body composition and development of abdominal obesity are distinct characteristic of Inflammatory Bowel Diseases (IBDs). Resistin, a white adipose tissue-secreted protein, play an important role in metabolism and inflammation. Aim: To evaluate serum resistin in ulcerative colitis (UC) and healthy controls and its association with anthropometric, body composition, inflammatory parameters and clinical disease activity in UC. Methods: Fifty UC patients and 43 healthy age and sex matched participants were recruited for this case-control study. Clinical disease activity of UC patients was determined according to the Powell-Tuck activity index. Anthropometric parameters and body composition were assessed in UC patients. Serum resistin, hs-CRP and white blood cell (WBC) count were evaluated, too. Univariate and multivariate regression analyses used to determine the association between parameters. Results: Serum resistin levels were significantly increased in UC patients compared with controls (P= 0.004). It was correlated with disease activity scores (P= 0.016), hs-CRP levels (P= 0.009) and fat mass (P= 0.023) in UC patients but not with anthropometric factors and lean body mass. Results have showed that the most sensitive independent predictors of resistin among patients with UC were inflammatory parameters (P= 0.015). Conclusion: We found elevated levels of resistin in mild to moderate UC patients compared to healthy subjects. It was strongly correlated with inflammatory parameters but not anthropometric factors and body composition.

Downloads

Download data is not yet available.
Abstract 116 | PDF Downloads 90