Correlation between inflammatory markers and organ dysfunction among Intensive Unit Care patients

Main Article Content

Seyed Mohammad Hosein Mousavi Jazayeri
Abdolrasoul Safaiyan
Alireza Ostadrahimi
Shahryar Hashemzadeh
Firouz Salehpour

Keywords

Enteral Nutrition, Tumor Necrosis Factor-alpha (TNF-α), Intensive Care Unit (ICU)

Abstract

Background: Nutrition in the Intensive Care Unit (ICU) encounters a variety of challenges. This study aimed to examine the correlation of Tumor Necrosis Factor-alpha (TNF-α) and high sensitive C-reactive protein (hs-CRP) with the Sequential Organ Failure Assessment (SOFA) score in traumatic ICU patients. Patients and Methods: Twenty five critically ill patients were recruited for assessment of the inflammatory factors’ correlation with the SOFA score. Statistical analyses were done using parametric tests. Results: Statistical analysis showed a strong correlation between TNF-α on day 3 of admission with SOFA scores on days 5 and 7 (r> 0.5). A similarly strong correlation also was seen between hs-CRP and SOFA on days 3 and 5 (r>0.5). Conclusion: The study results showed serum levels of TNF-α on day 3 of admission can predict organ dysfunction in traumatic ICU patients and TNF-α is a better prognostic factor than hs-CRP.

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