Crohn’s disease-associated interstitial lung disease mimicking sarcoidosis: a case report and review of the literature

Main Article Content

Choua Thao
Amir Lagstein
Tadashi Allen
Huseyin Erhan Dincer
Hyun Joo Kim

Keywords

Interstitial lung disease, Crohns disease, Sarcoidosis, Cryoprobe lung biopsy.

Abstract

Respiratory involvement in Crohn’s disease (CD) is a rare manifestation known to involve the large and small airways, lung parenchyma, and pleura. The clinical presentation is nonspecific, and diagnostic tests can mimic other pulmonary diseases, posing a diagnostic challenge and delay in treatment. We report a case of a 60-year-old female with a history of CD and psoriatic arthritis who presented with dyspnea, fever, and cough with abnormal radiological findings. Diagnostic testing revealed an elevated CD4:CD8 ratio in the bronchoalveolar lavage fluid, and cryoprobe lung biopsy results showed non-necrotizing granulomatous inflammation. We describe here the second reported case of pulmonary involvement mimicking sarcoidosis in Crohn’s disease and a review of the literature on the approaches to making a diagnosis of CD-associated interstitial lung disease. 

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