Bone grafting in the pre-antiseptic era(historical review):Creation of the first theories related to bone grafting: 1860-1880.

Main Article Content

Alexander Pankratov
Astemir Shaikhaliev


bone graft, periosteum, ossification, transplantation, amputation, bone defect, regeneration process, replantation.


This article examines the period of formation of the theoretical foundations of bone plastic surgery, and the ideas about bone regeneration in general, which predetermined the development of this branchsection of medical science in the following decades. The work covers the period from L. Ollier's experimental work to Operation W. Macewen’s operationMacewen (1881). At thethat time, there was a lively debatediscussion in the scientific literature, both regarding the fate of the transplanted bone fragment and about the sources of bone tissueregenerative regeneration. of bone tissue. Microscopic techniques have beenwere used for the first time to study this process, albeitalthough in a limited number of observations. The article analysesanalyzes the arguments of each of the parties involved in the debatediscussion. Although no general concept was developed at that time, the accumulated facts formed the basis forof subsequent clinical experiments made possible by the introduction of an antiseptic approach toin surgical practice.

Abstract 40 | PDF Downloads 62


Ollier L. Experimental and Clinical treatment of Bone Regeneration and artificial bone tissue production. In two tome. Paris. Victor Masson et Fils. 1867 – 443, 531p.
Ollier L. Artificial bone production by means of periosteum transplantation and bone graftsMemoires lus a la societe de biologie. Pendant l’anne 1859; Tom V (Annee 1858): 145-162
Pankratov A.S., Shaikhaliev A.I. Bone grafting in the pre-antiseptic era (historical review): Beginning of the journey. From antiquity to the 1860. Medicina Historica. 2022;6(3):e2022035
Bogdanovskij E.I., Karpinskij I.G. Experiments in the transfer of bones from one animal to another. Medical Bulletin. 1861;10:89
Abrazhanov A.A.Bone transplantation and filling. Dissertation. St Petersburg. S.P. Yakovlev Printing house 1900 – 117p.
Bredihin I.A. About bone revival from the periosteum in general and, in particular, after resection. Dissertation. Moscow: Grachev Printing house, 1862 - 70p.
Wolf J. Osteoplasty in its relations with surgery and physiology. Archiv fur Klinische Chirurgie. Hereusgegeben von B. Langenbeck. 1863: 183-294
Buchholz R. Some attempts at artificial bone formation. Virchow’s Arch. 1863:26(1-2);78-106
Macewen W. Observations concerning Transplantation of Bone. Illustrated by Case of Inter-human Osseous Transplantation, whereby over two-thirds of the Shaft of a Humerus was restored. Proceeding of the Royal Society of London. 1881; 32: 232-247
Lavrishcheva G.I., Onoprienko G.A. Morphological and clinical aspects of reparative regeneration of supporting organs and tissues. Moscow. Medicine, 1996 – 208p.
Virchow R. Cellular pathology as a teaching based on physiological and pathological histology. Berlin. Verlag von August Hirschwald, 1859 – 476p.
Rokitansky C. A Guide to pathological anatomy. Translated from the German by Dmitrij Min. Part 1. Moscow. University Printing House, 1847 – 510p.
Grekov I.I. Materials on the issue of bone defects of the skull and their treatment. Experimental and clinical study. Dissertation. St. Petersburg: Yakovlev Printing Association, 1901 - 164p.
Florance P. Notes on the dura mater or internal periosteum of the skull bones. Gazette medic de Paris. 1859;14:527
Rudnev M.F. Replantation and transplantation of whole tubular bones and bone pieces. Experimental study. Dissertation. St. Petersburg: Yakov Trey Printing house, 1880 - 49p.
Bajkov A.I. Bone marrow transplantation. Journal for Normal and Pathological Histology, Pharmacology and Clinical Medicine. 1870;1:132-135
Kosmovskij Yu.A. On wound healing after trepanation. Dissertation. St. Petersburg, Yakov Trey Printing House, 1871 - 29p.
Kosmovskij Yu.A. On the issue of engraftment of a piece of bone that has been trepanned on the cranial vault. Journal for Normal and Pathological Histology, Pharmacology and Clinical Medicine. 1873; 7: 48-56
Busch F. Experimental study of osteitis and necrosis. Langenbeck’s Arch. 1877;11-20:237-260
Bell B. Ollier on the reproduction of bone. Original communication. Edinburg Medical Journal. 1867; 12(2): 1122-1132
Langenbeck B. Bone – Formation after Resection of the Lower Jaw. Transaction s of the “German Society of Surgery” Sixth Congress. New York. D. Appleton & Company, 1878 - 6p.
Kosmovskij Yu.A. A case of a bone defect repair on the cranial vault. Journal for Normal and Pathological Histology, Pharmacology and Clinical Medicine. 1871;4:276-280
Bogdanovich U.YA. Materials on the development of bone grafting in Russia. Dissertation. Kazan, 1957 – 225 p.
Rauer A.E., Mihel'son N.M. Facial plastic surgery. Moscow: Medgiz, 1943- 256p.
Shimanovskij Yu.K. Defending Gritti operation in word and deed. Part 1. Military medical journal. 1868;5:1-21
Lister J. On the Antiseptic Principle in the Practice of Surgery. The British Medical Journal. 1867;21:246-248
Toledo-Pereyra L. H., Toledo M.M. A critical study of Lister's work on antiseptic surgery. Am J Surg 1976 Jun;131(6):736-44
Koch R. Investigation s into the Etiology of Traumatic Infective Diseases. Translated by Cheyne W.W. London. The New Sydenham Society, 1880 – 101p.
Urist M.R. Bone: formation by autoinduction. Science 1965;150(3698):893-9.
Lazzeri D., Gatti G.L., Romeo G., Balmelli B., Massei A. Bone Regeneration and Periosteoplasty: A 250-Year-Long History. Cleft Palate Craniofac J 2009;46(6):621-8.  
Clinical operative maxillofacial surgery: A guide for physicians / Ed. N.M. Aleksandrov. Leningrad: Medicina, 1985 – 448p.
Schenk RK, Willenegger H: Morphological findings in primary fracture healing. Symp Biol Hungarica. 1967; 7:75-86
Fridenshtejn A.Ya., Lalykina K.S.Bone tissue induction and osteogenic progenitor cells Moscow: Medicina, 1973 – 221p.

Most read articles by the same author(s)