Pulmonary Langerhans Cell Histiocytosis in a young Non-Smoking Female --Too many Rituals spoil the Lung: PLCH in a never smoker female

Pulmonary Langerhans Cell Histiocytosis in a young Non-Smoking Female --Too many Rituals spoil the Lung

PLCH in a never smoker female


  • Benhur Joel Shadrach Pulmonary, Critical care & Sleep Medicine, Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur
  • Diksha Agnihotri Department of Neurosciences, Academia Sinica, Taipei
  • Rishabh Goel Department of Pulmonary Medicine, Shahi Global Hospital, Gorakhpur
  • Hari haran Department of Pulmonary Medicine Sarojini Naidu Medical College, Agra


PLCH, female, non-cigarette smoke.


Pulmonary Langerhans cell histiocytosis (PLCH) is a rare idiopathic cystic interstitial granulomatous lung disease seen almost exclusively in cigarette smokers. It typically occurs between 20-40 years of age and equally distributed among both sexes. Management includes smoking cessation, avoidance of second-hand smoke, and close follow-up. Corticosteroids may be required in those with symptomatic disease with worsening lung function despite smoking cessation and progressive nodular stage of the disease. Here, we report an interesting case of biopsy-proven PLCH in a young never smoker female. Detailed questioning revealed significant exposure to incense smoke, highlighting a rare presentation of non-cigarette smoke-related PLCH. Avoidance of incense smoke combined with oral prednisolone (0.5mg/kg) tapered over 6 months led to complete resolution of symptoms, disappearance of nodules in high resolution computed tomography (HRCT) of the thorax and improvement in lung function.


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How to Cite

Shadrach BJ, Agnihotri D, Goel R, haran H. Pulmonary Langerhans Cell Histiocytosis in a young Non-Smoking Female --Too many Rituals spoil the Lung: PLCH in a never smoker female. Acta Biomed [Internet]. 2021 Apr. 30 [cited 2024 Jul. 23];92(S1):e2021138. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10133