Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma: Spontaneous remission in NK/T-cell Lymphoma during Covid-19

Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma

Spontaneous remission in NK/T-cell Lymphoma during Covid-19

Authors

  • Federico Pasin Internal Medicine Unit,ASST Cremona
  • Matteo Mascalchi Calveri ASST Cremona
  • Alberto Calabrese ASST Cremona
  • Ginevra Pizzarelli ASST Cremona
  • Isabel Bongiovanni ASST Cremona
  • Michele Andreoli ASST Cremona
  • Chiara Cattaneo ASST Brescia
  • Giovanni Rignanese ASST Cremona

Keywords:

SARS-CoV2 Covid-19 NK lymphoma EBV DNA Remission

Abstract

Covid-19 infection was a possible causal factor in the exhaustion and decrease number of NK clonal cells, resulting in a evident improvement of signs, symptoms and clinical features related to NK lymphoma refractory to previous immuno-chemiotherapy.

It has been shown that SARS-CoV2 binds to ACE2. Covid-19 may infect NK cells to suppress their functions, as NK cells express angiotensin converting enzyme 2 (ACE2). The excessive production of proinflammatory cytokines in Covid-19 infection may have played a crucial role in lymphodepletion. Although not published in Covid-19, other RNA viruses that cause acute pulmonary infections promote NK cell apoptosis.

In NK/T-cell lymphoma plasma EBV-DNA is a sensitive surrogate biomarker of lymphoma load. In this case, we also notice a dramatic transient reduction in plasmatic EBV-DNA viral copies during Covid-19 pneumonia other than NK clonal cells reduction, and after the infection resolution we described a lymphoma relapse as well as EBV-DNA increase and the rising in NK clonal cells count.

Although the mechanism leading to spontaneous remission remain uncharacterized, we hypothezised that a favorable adaptive immunity against concurrent viral infection could render an enhanced anti-tumor effect. We suppose COVID-19 infection have induced a transient remission in this patient affected with NK neoplasm.

References

Wang F, Nie J, Wang H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 Pneumonia. J Infect Dis. 2020 Mar 30. [Epub ahead of print]

Zheng M, Gao Y, Wang G, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol 2020 Mar 17. [Epub ahead of print]

Santos JM, Cervera-Carrascon V, Havunen R, et al. Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor AlphaReplaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy. Mol Ther 2018 Sep 5;26(9):2243-2254.

Snijder J, Mihyawi N, Frolov A, et al. Spontaneous remission in diffuse large cell lymphoma: a case report. J of Med Case Reports. 2019 13:28.

Musto P et al. Spontaneus remission in Acute Myeloid Leukaemia: A role for endogenous production of Tumour necrosis factor and Interleukin-2? Br J Haematol. 1994 Aug;87(4): 879-80.

Downloads

Published

07-09-2020

Issue

Section

CORRESPONDENCE/CASE REPORTS - SPECIAL COVID19

How to Cite

1.
Pasin F, Mascalchi Calveri M, Calabrese A, Pizzarelli G, Bongiovanni I, Andreoli M, et al. Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma: Spontaneous remission in NK/T-cell Lymphoma during Covid-19 . Acta Biomed [Internet]. 2020 Sep. 7 [cited 2024 Jul. 19];91(3):e2020047. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10141