The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury

The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury


  • Sara Torabi Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Farbod Bahreini Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  • Nima Rezaei Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


Angiotensin-converting enzyme 2, COVID-19, Lung injury


The novel coronavirus disease (COVID-19) has affected people around the world both physically and psychologically. As result, developing coronavirus-specific vaccine and/or therapeutics is now a top priority for public health agencies. Since our findings about COVID-19 are relatively new, the current knowledge about the molecular mechanism involved in pathogenicity and virulence of the novel coronavirus is not advanced. Understanding angiotensin-converting enzyme 2 (ACE2), the receptor for the coronavirus, is significantly important. To better illustrate the role of ACE2 in the severity of COVID-19 and the impact of currently used drugs on this receptor, this paper briefly reviews newly published articles in this regard.


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How to Cite

Torabi S, Bahreini F, Rezaei N. The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury. Acta Biomed [Internet]. 2020 Nov. 10 [cited 2024 Jul. 22];91(4):e2020142. Available from: