Antithrombotic prophylaxis in children and adolescent patients with SARS-CoV-2 (COVID-19) infection: A practical guidance for clinicians

Antithrombotic prophylaxis in children and adolescent patients with SARS-CoV-2 (COVID-19) infection: A practical guidance for clinicians

Authors

  • Mehran Karimi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz
  • Haleh Bozorgi Hematology Research Center, Shiraz University of Medical Sciences, Shiraz
  • Tahereh Zarei Hematology Research Center, Shiraz University of Medical Sciences, Shiraz
  • Mohammadreza Bordbar Hematology Research Center, Shiraz University of Medical Sciences, Shiraz
  • Ali Amanati Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Arash Safaei Hematology Research Center, Shiraz University of Medical Sciences, Shiraz
  • Vincenzo De Sanctis Coordinator of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A), Ferrara, Italy

Keywords:

SARS-Corona-Virus-2, COVID-19, venous thromboembolism, anticoagulation chemoprophylaxis, pediatric ‎

Abstract

Severe coronavirus disease 2019 (COVID-19) is often associated with features of hypercoagulable state which can manifest as venous thromboembolism (VTE) and/or microthrombosis. Given the high risk of VTE in critically ill COVID-19 patients, appropriate VTE prophylaxis seems to be an important part of managing these patients. Although many protocols regarding venous thromboembolism (VTE) prophylaxis or therapeutic (full-dose) anticoagulation have been conducted worldwide, primarily in hospitalised adult patients, details on paediatric patients, if included, are limited or incomplete. The current evidences suggest that anticoagulation therapy with low molecular weight heparins (LMWH) appears to be associated with better prognosis in patients with moderate to severe COVID-19 induced coagulopathies or elevated D-dimer levels.  Our recommendations are intended to offer guidance for anticoagulation prophylaxis and treatment in COVID-19 children and adolescent patients and not intend to supersede the clinician judgement. We are also conscious that several clinical questions deserve further studies and clarifications because this area is rapidly evolving.

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Published

10-11-2020

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Section

ORIGINAL INVESTIGATIONS/COMMENTARIES - SPECIAL COVID19

How to Cite

1.
Antithrombotic prophylaxis in children and adolescent patients with SARS-CoV-2 (COVID-19) infection: A practical guidance for clinicians. Acta Biomed [Internet]. 2020 Nov. 10 [cited 2024 Mar. 29];91(4):e2020170. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10720