Rising concerns of Mucormycosis (Zygomycosis) among COVID-19 patients; an analysis and review based on case reports in literature

Rising concerns of Mucormycosis (Zygomycosis) among COVID-19 patients; an analysis and review based on case reports in literature


  • Kamleshun Ramphul Department of Pediatrics, Shanghai Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine
  • Renuka Verma Guru Gobind Singh Medical College, Punjab, India https://orcid.org/0000-0002-8090-3319
  • Nomesh Kumar Liaquat University of Medicine and Health Sciences, Jamshroo, Pakistan https://orcid.org/0000-0002-4410-988X
  • Yogeshwaree Ramphul Sir Seewoosagur Ramgoolam National Hospital, Mauritius
  • Stephanie Mejias UNIBE School of Medicine, Santo Domingo, Dominican Republic
  • Petras Lohana Liaquat University of Medicine and Health Sciences, Jamshroo, Pakistan https://orcid.org/0000-0001-8427-1155


Mucormycosis, COVID-19, Fungal infection, Amphotericin B


As the world continues to struggle with the pandemic of COVID-19 (coronavirus disease 2019), several cases of mucormycosis have been reported in these patients with a high mortality rate. We conducted a review of literature and found 19 articles with 20 patients who developed mucormycosis during their COVID-19 infection.14 (70%) were males, and 6(30%) were females. While their mean age was 52.2 ± 17.3, affected men were older than females. Ten (50%) patients also had diabetes. Common clinical findings included ophthalmologic complaints, fever, shortness of breath, and facial pain. Amphotericin B was the most common antifungal used and 40% of cases needed surgical management of the infection. Steroid use was reported in around 12 cases (60%). Unfortunately, the mortality rate was 65% in this group of patients. Several changes in care should be brought for a consistent prevention, early diagnosis, and strong management of mucormycosis in COVID-19 patients.


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How to Cite

Rising concerns of Mucormycosis (Zygomycosis) among COVID-19 patients; an analysis and review based on case reports in literature. Acta Biomed [Internet]. 2021 Sep. 2 [cited 2024 Jun. 24];92(4):e2021271. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/11787