Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study

Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study


  • Marco Benazzo University of Pavia
  • Salvatore Leonardi University of Catania
  • Angelo Corsico University of Pavia
  • Amelia Licari University of Pavia
  • Michele Miraglia del Giudice University of Campania
  • Diego Peroni University of Pisa
  • Carmelo Salpietro University of Messina
  • Gian Luigi Marseglia University of Pavia
  • Giorgio Ciprandi


seasonal allergic rhinitis, children, quality of life, symptoms, cetirizine.


Background and aim Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continuous cetirizine treatment in a group of Italian children with SAR.

Methods Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment.

Results Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both).

Conclusions The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe.


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How to Cite

Benazzo M, Leonardi S, Corsico A, Licari A, Miraglia del Giudice M, Peroni D, et al. Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study. Acta Biomed [Internet]. 2020 Jun. 17 [cited 2024 Jul. 21];92(1):e2021003. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/9948