Main Article Content
bias, clinical aromatherapy, bergamot essential oil, NanoBEO, severe dementia, pain, agitation, I-MOBID-2, CONSORT
The use of complementary and integrative therapies is steadily growing though the quality of clinic evidence for the use of essential oils is hampered by several methodological biases. Lack of rigorous methodology in clinical studies with aromatherapy originates poor quality evidence and scientific response to overcome the biases of this field of research is needed. Accordingly, here we display a possible step-by-step preclinical-to-clinical pathway, that was followed for the essential oil of bergamot (BEO), to overcome typical biases of research in the field of essential oils, in order to provide good quality body of evidence.