Dietary creatine-guanidinoacetate acutely improves circulating creatine levels and running performance in healthy men and women Creatine-guanidinoacetate for creatine status and exercise performance

Main Article Content

Bogdan Andjelic
Nikola Todorovic
Milan Vranes
Sergej Ostojic


Creatine, Guanidinoacetate, Exercise, Bioenergetics, Women



Abstract 114 | PDF Downloads 64


1. Ostojic SM, Forbes SC. Perspective: creatine, a conditionally essential nutrient: building the case. Adv Nutr. 2022;13(1):34-37.
2. Stajer V, Trivic T, Drid P, Vranes M, Ostojic SM. A single session of exhaustive exercise markedly decreases circulating levels of guanidinoacetic acid in healthy men and women. Appl Physiol Nutr Metab 2016;41(10):1100-1103.
3. Stajer V, Vranes M, Ostojic SM. Correlation between biomarkers of creatine metabolism and serum indicators of peripheral muscle fatigue during exhaustive exercise in active men. Res Sports Med. 2020;28(1):147-154.
4. Joncquel-Chevalier Curt M, Cheillan D, Briand G, et al. Creatine and guanidinoacetate reference values in a French population. Mol Genet Metab. 2013;110(3):263-7.
5. Jovanov P, Vranes M, Sakac M, et al. Hydrophilic interaction chromatography coupled to tandem mass spectrometry as a method for simultaneous determination of guanidinoacetate and creatine. Analytica Chimica Acta. 2018;1028:96-103.
6. Semeredi S, Stajer V, Ostojic J, Vranes M, Ostojic SM. Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: a randomized, double-blind superiority trial. Nutrition. 2019;57:162-166.
7. Ostojic SM. Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: a novel approach? Biomed Pharmacother. 2017;91:238-240.
8. Ostojic SM, Jorga J. Guanidinoacetic acid in human nutrition: beyond creatine synthesis. Food Sci Nutr. 2023 Jan 11;11(4):1606-1611.

Most read articles by the same author(s)