Intake of Scrophularia buergeriana extract (Brainon®) shows memory improvement effects in a randomized, double-blind, placebo-controlled clinical study

Memory improvement effect of Brainon®


  • sung-kwon Lee Research Institute, NUON Co., Ltd., Seongnam, Republic of Korea
  • Hae-Lim Kim Research Institute, NUON Co., Ltd., Seongnam, Republic of Korea
  • Seong-Hyeon Park Research Institute, NUON Co., Ltd., Seongnam, Republic of Korea
  • Bong-Keun Choi Research Institute, NUON Co., Ltd., Seongnam, Republic of Korea
  • Dong-Ryung Lee Research Institute, NUON Co., Ltd., Seongnam, Republic of Korea
  • Seung-Hwan Yang Department of Biotechnology, Chonnam National University, Yeosu, Republic of Korea


Scrophularia buergeriana, Clinical trial, Memory improvement, Memory impairment, Health functional food


Background and aim: Scrophularia buergeriana (SB), also known as Hyun-Sam in Korea, is a traditional medicine used to alleviate fever, swollen skin, constipation, and other health issues. The aim of this study was to evaluate the efficacy and safety of Scrophularia buergeriana 70% ethanol extract (Brainon®) supplementation on memory improvement in adults who complained of memory impairment. Methods: Eighty volunteers were recruited from Wonkwang University, Korean Medicine Hospital in Iksan, Republic of Korea. Participants were given either a daily dose of 300 mg of Brainon® or a placebo. In this study, the Korean Mini-Mental State Examination (K-MMSE), a Computerized Neurocognitive function Test (CNT), Digit Span Test, serum Brain-Derived Neurotrophic Factor (BDNF), and interleukin-6 (IL-6) were used to check effects of Brainon® on memory function in those with mild memory impairment. Results: Consumption of Brainon® resulted in significant improvements in immediate recall total score of the CNT-Verbal learning test, correct response and omission error items of the CNT-Visual C.P.T, backward recall of the Digit span test, and serum levels of BDNF and IL-6. Clinically significant adverse events or physical changes were not observed in this study. Conclusions: This clinical trial demonstrated for the first time the efficacy and safety of SB extract (Brainon®) in enhancing memory function. The results of this study indicate that consumption of Brainon® could lead to an improvement in memory without any adverse effects. Based on these research findings, Brainon® is expected to be developed as a health functional food ingredient.


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Original articles

How to Cite

Lee sung- kwon, Kim H-L, Park S-H, Choi B-K, Lee D-R, Yang S-H. Intake of Scrophularia buergeriana extract (Brainon®) shows memory improvement effects in a randomized, double-blind, placebo-controlled clinical study: Memory improvement effect of Brainon®. Progr Nutr [Internet]. 2024 Jun. 24 [cited 2024 Jul. 15];26(2):e2024017. Available from: