Principal component analysis of clinical characteristics of pulmonary sarcoidosis with or without extrapulmonary lesions: a single-center observational study in Japan

Main Article Content

Yohei Maki
Jun Miyata
Ryohei Suematsu
Hisashi Sasaki
Yoshifumi Kimizuka
Yuji Fujikura
Akihiko Kawana

Keywords

Bronchoalveolar lavage fluid, Eosinophils, Neutrophils, Principal component analysis, Sarcoidosis, Extrapulmonary sarcoidosis

Abstract 247 | PDF Downloads 174

References

1. Arkema EV, Cozier YC. Sarcoidosis epidemiology: recent estimates of incidence, prevalence and risk factors. Curr Opin Pulm Med. 2020;26:527–34. doi: 10.1097/mcp.0000000000000715.
2. Li CW, Tao RJ, Zou DF, Li MH, Xu X, Cao WJ. Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China. BMJ Open. 2018;8:e018865. doi: 10.1136/bmjopen-2017-018865.
3. Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020; 201:e26-e51. doi: 10.1164/rccm.202002-0251ST.
4. Kraaijvanger R, Janssen Bonás M, Vorselaars ADM, Veltkamp M. Biomarkers in the diagnosis and prognosis of sarcoidosis: current use and future prospects. Front Immunol. 2020;11:1443. doi: 10.3389/fimmu.2020.01443.
5. Ziegenhagen MW, Rothe ME, Schlaak M, Müller-Quernheim J. Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis. Eur Respir J. 2003;21:407–13. doi: 10.1183/09031936.03.00010403
6. Belperio JA, Shaikh F, Abtin F, et al. Extrapulmonary sarcoidosis with a focus on cardiac, nervous system, and ocular involvement. EClinicalMedicine. 2021;37:100966. doi: 10.1016/j.eclinm.2021.100966.