Flashy lungs and sarcoidosis: not always a sign of disease activity

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Yousif A. Lucinian
Patrick Martineau
Francois Harel
Matthieu Pelletier-Galarneau


Methotrexate, Pneumonitis, Sarcoidosis, PET, FDG, Fluorodeoxyglucose


This is the case of a 68-year-old man with known cardiac sarcoidosis undergoing treatment with methotrexate who presented with new onset of dyspnea and lipothymia. FDG-PET/CT revealed pathological uptake within lung parenchyma which resolved following discontinuation of methotrexate, compatible with methotrexate-induced pneumonitis. This is the first case of methotrexate-induced pneumonitis documented by FDG-PET/CT.

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