Validation of the King’s Sarcoidosis Questionnaire (KSQ) in a Dutch sarcoidosis population

Main Article Content

Mirjam J. G. van Manen
Monique Wapenaar
Bert Strookappe
Marjolein Drent
Marjon Elfferich
Jolanda de Vries
Harry R. Gosker
Surinder S. Birring
Amit S. Patel
Leon van den Toorn
Bernt van den Blink
Karin Boomars
Elske Hoitsma
Marlies S. Wijsenbeek

Keywords

Sarcoidosis, Health status, Questionnaire, Quality of Life

Abstract

ABSTRACT

Background

The King’s Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health status using five modules (General Health Status, Lung, Eyes, Skin, Medication) in patients with sarcoidosis. The KSQ was only validated in one English sarcoidosis cohort.

Objective

The aim of this study was to validate the KSQ in a Dutch sarcoidosis population.

Methods

The KSQ was translated according to international guidelines and tested in interviews with patients. Consecutive outpatients completed multiple questionnaires twice, two weeks apart. Construct validity, internal consistency and repeatability were determined.

Results

Of the 98 patients included 85 had lung, 22 skin and 24 eye disease. There was good construct validity of the KSQ General Health Status module against the World Health Organization Quality of Life-BREF questionnaire. The Medication module correlated weak to moderate with most questionnaires. The correlations with organ-specific questionnaires varied from strong for Eyes (r=0.75), Skin (r=-0.62) to moderate for Lung (r=-0.45 with MRC breathlessness scale). Internal consistency was good for all KSQ modules (Cronbach’s α 0.72-0.93). Intraclass correlation coefficients (0.70-0.90) and Bland-Altman plots showed good repeatability of the KSQ.

Conclusion

The Dutch KSQ is the first translation of the English KSQ, validated in a Dutch sarcoidosis population.

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