Dr Hashimoto and the discovery of autoimmune hypothyroidism

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Natasa Kustrimovic https://orcid.org/0000-0002-5524-5238
Gaia Francesca Maria Fazzino
Claudia Ghirardello
Ilaria Mariani
Eliana Piantanida
Maria Laura Tanda
Daniela Gallo
Lorenzo Mortara

Keywords

Hashimoto’s disease, autoimmune thyroiditis, hypothyroidism, lymphocyte

Abstract

Hashimoto’s disease also known as Hashimoto’s thyroiditis (HT), is one of the most common autoimmune diseases involving the thyroid gland. HT that it is an organ-specific autoimmune disorder characterized by immune cell infiltration into thyroid tissue and thyroid-specific autoantibodies, causing thyroid gland destruction and, eventually, hypothyroidism which is the common clinical manifestation. The discovery of HT was a significant step in the history of medicine and paved the way toward the discovery of autoimmunity and endocrine disorders. HT was discovered by Dr Hakaru Hashimoto over 100 years ago. Surprisingly, it took several decades to be recognised as separate disease and acknowledged as a discovery of Dr Hashimoto. Herein, we summarize what is known of Dr Hashimoto biography and his discovery in order to shine a light on one of the most important discoveries linked to the thyroid disease and autoimmune disorders as well.
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References

1. Brown RS. Autoimmune thyroid disease: unlocking a complex puzzle. CurrOpinPediatr 2009; 21:523-8.
2. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med 2003; 348:2646-55.
3. Feldt-Rasmussen U. Hashimoto's thyroiditis as a risk factor for thyroid cancer. Curr Opin Endocrinol Diabetes Obes 2020; 27:364-71.
4. Volpe R (1989). "The Life of Doctor Hakaru Hashimoto". Autoimmunity 1989;
3:243–5.
5. Hashimoto K. My father and his teachers. Endocr J 2002; 49:389-91.
6. Hashimoto H. ZurKenntniss der lymphomato ̈sen Vernderung der Shilddru ̈se (Struma lymphomatosa). Arch LlinChir 1912; 97:219–48.
7. Amino N, Tada H, Hidaka Y, Hashimoto K. Hashimoto's disease and Dr. Hakaru Hashimoto. Endocr J 2002; 49:393-7.
8. Riedel BMCL. (1896) Die chronische zur Bildung eisenharter Tumoren fuhrende Entzundung der Schilddruse. Verh Dtsch Ges Chir 1896; 25:101–5.
9. Sawin CT. The heritage of Dr. Hakaru Hashimoto (1881-1934). Endocr J 2002; 49:399-403. doi: 10.1507/endocrj.49.399.
10. Takami HE, Miyabe R, Kameyama K. Hashimoto's thyroiditis. World J Surg 2008; 32:688-92.
11. Simmonds M. Uber lympnatische Herde in der Schilddrusse. Virchows Arch Pathol Anat Physiol 1913; 211:73–89.
12. Heineke. Die chronischethyreoiditis. Deut Zeit Chir 1914; 129:189-220.
13. Reist A. UberchronischeThyreoiditis. Frankf Z Pathol 1922; 28:141–200.
14. Graham A. Riede’s struma in contrast to struma lymphomatosa (Hashimoto). West J Surg 1931; 39:681–9.
15. Graham A, McCullagh EP. Atrophy and fibrosis associated with lymphoid tissue in the thyroid. Struma lymphomatosa (Hashimoto). Arch Surg 1932; 22:548-67.
16. Hertzler AE. Surgical pathology of the thyroid gland. J.B.Lippincott Co., Philadephia; p.191. 1935.
17. Means JH. The thyroid and its disease. J.B.Lippincott Co. Philadelphia;1937.
18. Joll CA. The pathology, diagnosis and treatment of Hashimoto’s disease (struma lymphomatosa). Brit J Surg 1939; 27:351-89.
19. McGavack TH. The thyroid. C.V.Mosby Co., St. Louis; 1951.
20. Rose NR, Witebsky E. Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol 1956; 76:417-27.
21. Witebsky E, Rose NR, Paine JR, Egan RW. Thyroid-specific autoantibodies. Ann N Y Acad Sci 1957; 69:669-77.
22. Weetman AP. An update on the pathogenesis of Hashimoto's thyroiditis. J Endocrinol Invest 2021; 44:883-90.
23. Doniach D, Roitt IM. Hakaru Hashimoto. Lancet 1962; 1074.
24. McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine 2012; 42:252-65.
25. Hasham A, Tomer Y. Genetic and epigenetic mechanisms in thyroid autoimmunity. Immunol Res 2012; 54:204-13.
26. Cogni G, Chiovato L. An overview of the pathogenesis of thyroid autoimmunity. Hormones (Athens). 2013; 12:19-29.
27. Ruggeri RM, Trimarchi F. Iodine nutrition optimization: are there risks for thyroid autoimmunity? J Endocrinol Invest 2021; 44:1827-35.
28. Ruggeri RM, D'Ascola A, Vicchio TM, et al. Selenium exerts protective effects against oxidative stress and cell damage in human thyrocytes and fibroblasts. Endocrine 2020; 68:151-62.
29. Gallo D, Mortara L, Gariboldi MB, et al. Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review. J Endocrinol Invest 2020; 43:413-29.
30. Gallo D, Bruno A, Gallazzi M et al., Immunomodulatory role of vitamin D and selenium supplementation in newly diagnosed Graves’ disease patients during methimazole treatment. Front Endocrinol (Lausanne). 2023;14:1145811.
31. Ajjan RA, Weetman AP. The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding. Horm Metab Res 2015; 47:702-10.
32. Gallo D, Piantanida E, Veronesi G, et al. Physical performance in newly diagnosed hypothyroidism: a pilot study. J Endocrinol Invest 2017; 40:10991106.
33. Piantanida E, Gallo D, Veronesi G, et al. Masked hypertension in newly diagnosed hypothyroidism: a pilot study. J Endocrinol Invest 2016; 39:1131-8.
34. Jonklaas J, Bianco AC, Bauer AJ, et al., American Thyroid Association Task Force on Thyroid Hormone Replacement. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 24:1670-751.

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