Sleep health in a bilingual European region: lessons from a population-based research programme in South Tyrol, Italy

Sleep health in a bilingual European region: lessons from a population-based research programme in South Tyrol, Italy

Authors

  • Dietmar Ausserhofer Institute of General Practice and Public Health, Claudiana College of Health Professions, Bolzano, Italy https://orcid.org/0000-0002-0319-4766
  • Stefano Lombardo Provincial Institute of Statistics (ASTAT), Bolzano, Italy https://orcid.org/0009-0009-8034-8480
  • Verena Barbieri Institute of General Practice and Public Health, Claudiana College of Health Professions, Bolzano, Italy https://orcid.org/0000-0002-5934-9472
  • Giuliano Piccoliori Institute of General Practice and Public Health, Claudiana College of Health Professions, Bolzano, Italy https://orcid.org/0000-0003-1974-4184
  • Doris Hager von Strobele Prainsack Institute of General Practice and Public Health, Claudiana College of Health Professions, Bolzano, Italy
  • Christian Josef Wiedermann Institute of General Practice and Public Health, Claudiana College of Health Professions, Bolzano, Italy

Keywords:

sleep quality; health literacy; patient activation; adolescent mental health; prescribing patterns; South Tyrol

Abstract

Background. Sleep disorders are highly prevalent among European adults, with disease-specific estimates ranging from 10% for insomnia to 18% for obstructive sleep apnoea; however, sleep health remains underrepresented in national public health strategies. Population-based evidence on sleep quality and its broader determinants is scarce in Italy, where the only nationally representative survey was conducted in 2002. This narrative review synthesizes a coordinated sleep health research program in South Tyrol, a bilingual region in Northern Italy.

Methods. Six peer-reviewed publications (2025–2026) based on a representative adult survey (n = 2,090), adolescent mental health screening (n = 1,471), and regional pharmaceutical data were reviewed following the SANRA framework. Contextual literature was identified using PubMed and the Consensus academic search engine.

Results. Among adults, 18% met the criterion for poor sleep quality (B-PSQI ≥6), and 28% slept six hours or less. Latent profile analysis identified a Struggling Navigators cluster (25.8%) characterized by poor sleep, low health literacy, and elevated health care utilization. Mistrust of professional health information was independently associated with poor sleep and not mediated by health behaviors. Benzodiazepine consumption was approximately half the national average, offset by higher sedating antidepressant use, mirroring the German-language prescribing culture. Among adolescents, each additional hour of sleep reduced the odds of anxiety by 31% (OR = 0.69; 95% CI: 0.56–0.84) and depression in males by 40% (OR = 0.60; 95% CI: 0.44–0.81). Patient activation partially mediated the chronic disease–sleep relationship (4.7–6.3%) with disease-specific variation.

Discussion. The findings provide rare European population-based evidence on the health literacy–sleep and patient activation–sleep associations, introduce health information mistrust as a novel correlate of sleep quality, and document culturally shaped prescription patterns within a single national framework. The results support the integration of sleep into public health strategies and offer a replicable model for regional surveillance.

References

1. Bassetti CLA, Welter LS, Montes-Martinez M, Mühlberger N, Boon P, Berger T, et al. Epidemiology and economic burden of sleep disorders in Europe. Eur J Neurol. 2026;33:e70463. doi:10.1111/ene.70463

2. Lim D, Najafi A, Afifi L, Bassetti C, Buysse D, Han F, et al. The need to promote sleep health in public health agendas across the globe. Lancet Public Health. 2023 Oct;8(10):e820-e826. doi: 10.1016/S2468-2667(23)00182-2.

3. Ricciardi W, Tarricone R. The evolution of the Italian National Health Service. Lancet. 2021;398:2193–206. doi:10.1016/S0140-6736(21)01733-5

4. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, et al. National Sleep Foundation’s sleep quality recommendations: first report. Sleep Health. 2017;3:6–19. doi:10.1016/j.sleh.2016.11.006

5. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5-TR. 5th ed. Washington, DC: American Psychiatric Association Publishing; 2022.

6. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213. doi:10.1016/0165-1781(89)90047-4

7. Fabbri M, Beracci A, Martoni M, Meneo D, Tonetti L, Natale V. Measuring subjective sleep quality: a review. Int J Environ Res Public Health. 2021;18:1082. doi:10.3390/ijerph18031082

8. Ohayon M, Smirne S. Prevalence and consequences of insomnia disorders in the general population of Italy. Sleep Med. 2002;3(2):115–20. doi:10.1016/S1389-9457(01)00158-7

9. Godos J, Ferri R, Caraci F, Cosentino FII, Castellano S, Galvano F, et al. Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults. Nutrients. 2019 Apr 28;11(5):976. doi: 10.3390/nu11050976.

10. Favaretto E, Gögele M, Bedani F, Giovannini S, Pramstaller P, Perugi G, et al. The influence of affective temperaments on sleep quality in a general population sample. Data report from the CHRIS study. J Affect Disord. 2025 Jul 1;380:162-170. doi: 10.1016/j.jad.2025.03.055.

11. Amerio A, Lugo A, Stival C, Fanucchi T, Gorini G, Pacifici R, et al. COVID-19 lockdown impact on mental health in a large representative sample of Italian adults. J Affect Disord. 2021;292:398–404. doi:10.1016/j.jad.2021.05.117

12. Casagrande M, Favieri F, Tambelli R, Forte G. The enemy who sealed the world: effects quarantine due to the COVID-19 on sleep quality, anxiety, and psychological distress in the Italian population. Sleep Med. 2020;75:12–20. doi:10.1016/j.sleep.2020.05.011

13. Breda M, Belli A, Esposito D, Di Pilla A, Melegari M, Delrosso L, et al. Sleep habits and sleep disorders in Italian children and adolescents: a cross-sectional survey. J Clin Sleep Med. 2023;19:659–72. doi:10.5664/jcsm.10400

14. Varghese N, Santoro E, Lugo A, Madrid-Valero J, Ghislandi S, Torbica A, et al. he Role of Technology and Social Media Use in Sleep-Onset Difficulties Among Italian Adolescents: Cross-sectional Study. J Med Internet Res. 2021 Jan 21;23(1):e20319. doi: 10.2196/20319.

15. Benzi I, Gallus S, Santoro E, Barone L, Cavallo F, Coppola L, et al. Psychosocial determinants of sleep difficulties in adolescence: the role of perceived support from family, peers, and school in an Italian HBSC sample. Eur J Pediatr. 2023;182:2625–34. doi:10.1007/s00431-023-04934-0

16. Gesi C, La-Torraca-Vittori P, Madonia N, Segù M, Salvi V, Cerveri G, et al. Exploring suicidal ideation and its correlates among Italian adolescents: the role of sleep quality. Sleep Med. 2026 Jan;137:106897. doi: 10.1016/j.sleep.2025.106897.

17. Sampasa-Kanyinga H, Colman I, Goldfield G, Janssen I, Wang J, Podinic I, et al. Combinations of physical activity, sedentary time, and sleep duration and their associations with depressive symptoms and other mental health problems in children and adolescents: a systematic review. Int J Behav Nutr Phys Act. 2020 Jun 5;17(1):72. doi: 10.1186/s12966-020-00976-x.

18. Naghavi M, Zamagni G, Abbafati C, Armocida B, Agodi A, Alicandro G, et al. State of health and inequalities among Italian regions from 2000 to 2021: a systematic analysis based on the Global Burden of Disease Study 2021. Lancet Public Health. 2025;10(4):e309-e320. doi:10.1016/S2468-2667(25)00045-3

19. Baccolini V, Rosso A, Di Paolo C, Isonne C, Salerno C, Migliara G, et al. What is the prevalence of low health literacy in European Union member states? A systematic review and meta-analysis. J Gen Intern Med. 2021;36:753–61. doi:10.1007/s11606-020-06407-8

20. Liu Y, Xue W, Sheng Y, Wang S, Gong R, Liu S, et al. Age-specific associations between eHealth literacy and sleep quality among adults: cross-sectional study. J Med Internet Res. 2025;27:e75813. doi:10.2196/75813

21. Duffy A, King N, Rivera D, Pankow K, Cunningham S, Tetzlaff E, et al. A longitudinal quasi-experimental study of a pedagogical approach to supporting undergraduate well-being and mental health: digital interdisciplinary accredited elective mental health literacy university course. BJPsych Open. 2026;12:e64. doi:10.1192/bjo.2025.10960

22. Hibbard J, Stockard J, Mahoney E, Tusler M. Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res. 2004;39(4 Pt 1):1005–26. doi:10.1111/j.1475-6773.2004.00269.x

23. Greene J, Hibbard J, Sacks R, Overton V, Parrotta C. When patient activation levels change, health outcomes and costs change, too. Health Aff (Millwood). 2015;34(3):431–7. doi:10.1377/hlthaff.2014.0452

24. Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Grošelj LD, Ellis J, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017 Dec;26(6):675-700. doi: 10.1111/jsr.12594.

25. Tardy A, Marguet S, Costantino H, Stewart A, Mackie D, Saba G, et al. Profile and quality of life of the adult population in good health according to the level of vitality: European NHWS cross sectional analysis. BMC Public Health. 2023 Jun 5;23(1):1061. doi: 10.1186/s12889-023-15754-0.

26. Armstrong K, Rose A, Peters N, Long JA, McMurphy S, Shea JA. Distrust of the health care system and self-reported health in the United States. J Gen Intern Med. 2006;21:292–7. doi:10.1111/j.1525-1497.2006.00396.x

27. Palmer A, Gorman S. Misinformation, trust, and health: the case for information environment as a major independent social determinant of health. Soc Sci Med. 2025;381:118272. doi:10.1016/j.socscimed.2025.118272

28. Williams P, Bellantuono C, Fiorio R, Tansella M. Psychotropic drug use in Italy: national trends and regional differences. Psychol Med. 1986;16:841–50. doi:10.1017/S0033291700011855

29. Piovani D, Clavenna A, Cartabia M, Bonati M. Psychotropic medicine prescriptions in Italian youths: a multiregional study. Eur Child Adolesc Psychiatry. 2016;25:235–45. doi:10.1007/s00787-015-0726-0

30. Colletti N, Lombardo S. Südtiroler Sprachbarometer: Sprachgebrauch und Sprachidentität in Südtirol 2025 [German]. Bozen: Landesinstitut für Statistik (ASTAT), Autonome Provinz Bozen-Südtirol; 2025.

31. Dekret des Präsidenten der Republik vom 31. August 1972, Nr. 6701 [German]. 1972.

32. Ausserhofer D, Barbieri V, Lombardo S, Gärtner T, Eisendle K, Piccoliori G, et al. Primary and emergency care use: the roles of health literacy, patient activation, and sleep quality in a latent profile analysis. Behav Sci (Basel). 2025 May 24;15(6):724. doi: 10.3390/bs15060724.

33. Ausserhofer D, Piccoliori G, Engl A, Marino P, Barbieri V, Lombardo S, et al. Sleep problems and sleep quality in the general adult population living in South Tyrol (Italy): a cross-sectional survey study. Clocks Sleep. 2025 May 8;7(2):23. doi: 10.3390/clockssleep7020023.

34. Ausserhofer D, Wiedermann CJ, Barbieri V, Lombardo S, Gärtner T, Eisendle K, et al. Health information mistrust is directly associated with poor sleep quality: evidence from a population-based study. Healthcare (Basel). 2025 Jun 10;13(12):1385. doi: 10.3390/healthcare13121385.

35. Barbieri V, Piccoliori G, Engl A, Wiedermann CJ. Gender specific mental health among adolescents in Northern Italy: a cross-sectional study. Front Public Health. 2026 Jan 16;13:1705580. doi: 10.3389/fpubh.2025.1705580.

36. Wiedermann CJ, Barbieri V, Lombardo S, Gärtner T, Eisendle K, Piccoliori G, et al. Sleep quality and patient activation in chronic disease: a cross-sectional mediation analysis. Clocks Sleep. 2025 Aug 22;7(3):44. doi: 10.3390/clockssleep7030044

37. Wiedermann CJ, Sangermano K, Marino P, Ausserhofer D, Engl A, Piccoliori G. Distinct regional pattern of sedative psychotropic drug use in South Tyrol: a comparison with national trends in Italy. Pharmacy (Basel). 2025 Feb 21;13(2):32. doi: 10.3390/pharmacy13020032.

38. Baethge C, Goldbeck-Wood S, Mertens S. SANRA: a scale for the quality assessment of narrative review articles. Res Integr Peer Rev. 2019;4:5. doi:10.1186/s41073-019-0064-8

39. Koyanagi A, Garin N, Olaya B, Ayuso-Mateos JL, Chatterji S, Leonardi M, et al. Chronic conditions and sleep problems among adults aged 50 years or over in nine countries: a multi-country study. PLoS One. 2014;9:e114742. doi:10.1371/journal.pone.0114742

40. Hsu MF, Lee KY, Lin TC, Liu WT, Ho SC. Subjective sleep quality and association with depression syndrome, chronic diseases and health-related physical fitness in the middle-aged and elderly. BMC Public Health. 2021;21:164. doi:10.1186/s12889-021-10206-z

41. Scott AJ, Correa AB, Bisby MA, Chandra SS, Rahimi M, Christina S, et al. Cognitive behavioral therapy for insomnia in people with chronic disease: a systematic review and meta-analysis. JAMA Intern Med. 2025;185:1350–61. doi:10.1001/jamainternmed.2025.4610

42. Slopen N, Lewis TT, Williams DR. Discrimination and sleep: a systematic review. Sleep Med. 2016;18:88–95. doi:10.1016/j.sleep.2015.01.012

43. Grandner MA, Hale L, Jackson N, Patel NP, Gooneratne NS, Troxel WM. Perceived racial discrimination as an independent predictor of sleep disturbance and daytime fatigue. Behav Sleep Med. 2012;10:235–49. doi:10.1080/15402002.2012.654548

44. Riemann D, Espie CA, Altena E, Arnardottir ES, Baglioni C, Bassetti CLA, et al. The European insomnia guideline: an update on the diagnosis and treatment of insomnia 2023. J Sleep Res. 2023;32:e14035. doi:10.1111/jsr.14035

45. Palagini L, Brugnoli R, Dell’Osso BM, Di Nicola M, Maina G, Martinotti G, et al. Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: results of European neuropsychopharmacology and sleep expert’s consensus group. Sleep Med. 2025;128:117–26. doi:10.1016/j.sleep.2025.01.033

46. Nicodemo C, Orso CE, Tealdi C. Overseas general practitioners (GPs) and prescription behaviour in England. Health Policy. 2024;140:104967. doi:10.1016/j.healthpol.2023.104967

47. Chan FKI, Moraga MT, Habib B, Girard N, Boulet JR, Tamblyn R. Does physicians’ clinical competence, communication ability, or cultural background influence potentially inappropriate prescribing of benzodiazepines and Z-drugs among older adults with insomnia? Pharmacoepidemiol Drug Saf. 2024;33:e70068. doi:10.1002/pds.70068

48. Ma TT, Wang Z, Qin X, Ju C, Lau WCY, Man KKC, et al. Global trends in the consumption of benzodiazepines and Z-drugs in 67 countries and regions from 2008 to 2018: a sales data analysis. Sleep. 2023;46:zsad124. doi:10.1093/sleep/zsad124

49. Soyka M, Wild I, Caulet B, Leontiou C, Lugoboni F, Hajak G. Long-term use of benzodiazepines in chronic insomnia: a European perspective. Front Psychiatry. 2023;14:1212028. doi:10.3389/fpsyt.2023.1212028

50. Ravens-Sieberer U, Devine J, Napp AK, Kaman A, Saftig L, Gilbert M, et al. Three years into the pandemic: results of the longitudinal German COPSY study on youth mental health and health-related quality of life. Front Public Health. 2023;11:1129073. doi:10.3389/fpubh.2023.1129073

51. Ludwig-Walz H, Dannheim I, Pfadenhauer LM, Fegert JM, Bujard M. Anxiety increased among children and adolescents during pandemic-related school closures in Europe: a systematic review and meta-analysis. Child Adolesc Psychiatry Ment Health. 2023;17:74. doi:10.1186/s13034-023-00612-z

52. Barbieri V, Wiedermann CJ, Kaman A, Erhart M, Piccoliori G, Plagg B, et al. Quality of life and mental health in children and adolescents after the first year of the COVID-19 pandemic: a large population-based survey in South Tyrol, Italy. Int J Environ Res Public Health. 2022;19:5220. doi:10.3390/ijerph19095220

53. Barbieri V, Wiedermann CJ, Piccoliori G, Mahlknecht A, Plagg B, Ausserhofer D, et al. Evolution of youth’s mental health and quality of life during the COVID-19 pandemic in South Tyrol, Italy: comparison of two representative surveys. Children (Basel). 2023;10:895. doi:10.3390/children10050895

54. Short MA, Booth SA, Omar O, Ostlundh L, Arora T. The relationship between sleep duration and mood in adolescents: a systematic review and meta-analysis. Sleep Med Rev. 2020;52:101311. doi:10.1016/j.smrv.2020.101311

55. Evanger LN, Saxvig IW, Pallesen S, Gradisar M, Lie SA, Bjorvatn B. Associations between sleep patterns, circadian preference, and anxiety and depression: a two-year prospective study among Norwegian adolescents. Clocks Sleep. 2025;7:26. doi:10.3390/clockssleep7020026

56. López-Gil JF, Solmi M, García-Hermoso A, Vancampfort D, Fabiano N, Schuch FB, et al. Twenty-four-hour movement guidelines and depressive symptoms: association, temporal trends and moderators over a ten-year period among 45,297 US adolescents. Eur Child Adolesc Psychiatry. 2025;34:2507–20. doi:10.1007/s00787-025-02663-3

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Published

2026-05-15

Issue

Section

Review

How to Cite

1.
Ausserhofer D, Lombardo S, Barbieri V, Piccoliori G, Hager von Strobele Prainsack D, Wiedermann CJ. Sleep health in a bilingual European region: lessons from a population-based research programme in South Tyrol, Italy. Ann Ig. 2026;38(1):18764. doi:10.7416/ai.2026.18764