High-risk follicular lymphoma patients: identification and treatment

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Stefano Luminari
Francesco Merli


Follicular Lymphoma, Prognosis, Prognostic factors, High risk, early progression,


Over the last 15 years, the outcome of patients with follicular lymphoma (FL) has dramatically improved mainly as a result of effective therapies and of a better understanding of lymphoma biology. Although progression-free survival is approximately 10 years with standard treatment and overall survival upwards of 20 years, the clinical behavior among individual patients is highly heterogenous, and a significant number of subjects have a higher and earlier risk of dying from FL within a few years from diagnosis. In this article, we provide an overview of available prognostic tools that can be used to identify high-risk patients with FL and describe which therapies are available and can be recommended for this group of hard-to-treat FL patients.


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