Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas

Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas

Authors

  • Stefano Mancini Department of Internal Medicine and Rehabilitation, Santa Maria Bianca Hospital, AUSL Modena, Via A. Fogazzaro, 6 – 41037 Mirandola, Modena, Italy
  • Silvia Alboni Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy
  • Giorgio Mattei PhD Program in Labour, Development and Innovation, Marco Biagi Department of Economics and Marco Biagi Foundation, University of Modena and Reggio Emilia, Via Jacopo Berengario, 51 – 41121 Modena, Italy
  • Giulia Rioli Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy
  • Paola Sena Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy
  • Mattia Marchi Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy
  • Andrea Sacchetti Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy https://orcid.org/0000-0003-1403-6541
  • Valentina Boarino Gastrointestinal Endoscopy Unit, University of Modena and Reggio Emilia, Via del Pozzo, 71 – 41124 Modena, Italy
  • Luca Roncucci Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Via del Pozzo, 71 – 41124 Modena, Italy
  • Gian Maria Galeazzi Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy
  • Silvia Ferrari Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

Keywords:

colorectal adenoma; metabolic syndrome; psycho-neuro-immuno-endocrinological approach; anxiety; depression

Abstract

Background and aim of the work Colorectal mucosal precancerous lesions, metabolic syndrome (MetS) and psychiatric disorders may share a common low-grade local and systemic inflammation. Aim is to report on preliminary data concerning a research adopting a psycho-neuro-endocrine-immune (PNEI) approach to study outpatients undergoing colonoscopy. Methods A sample of patients undergoing colonoscopy was cross-sectionally investigated. Data on colorectal adenomas, MetS, early atherosclerosis, anxious-depressive symptoms, personality traits, and inflammatory markers were statistically analyzed. Results Sixty-two patients were recruited (female 50%, mean age: 60.8±9.4 years). The prevalence of adenomas and MetS was respectively of 45.2% and 41.9%. Anxiety and depressive symptoms were detected in 16 (32.7%) and 9 (18.4%) subjects, respectively. The presence of adenomas positively correlated with male sex (p=0.01), age (p<0.01), IL-6 (p=0.03), hsCRP (p=0.04), and MetS (p=0.03); it was also associated with hsCRP concentration (aOR=3.81, p=0.03). Conclusions Proinflammatory atherogenic status, psychological traits, increased mucosal inflammation, and metabolic parameters may share a common a pathogenic mechanism, worth studying.

Author Biographies

Giorgio Mattei, PhD Program in Labour, Development and Innovation, Marco Biagi Department of Economics and Marco Biagi Foundation, University of Modena and Reggio Emilia, Via Jacopo Berengario, 51 – 41121 Modena, Italy

Additional affiliation: Association for Research in Psychiatry, Via Carlo Alberto Dalla Chiesa, 33 – 41051 Castelnuovo Rangone, Modena, Italy

Giulia Rioli, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

Additional affiliation: PhD Program in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy.

Gian Maria Galeazzi, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

Additional affiliation: Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

Silvia Ferrari, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

Additional affiliation: Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Via Giuseppe Campi, 287 – 41125 Modena, Italy

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Published

30-09-2020

How to Cite

1.
Mancini S, Alboni S, Mattei G, Rioli G, Sena P, Marchi M, et al. Preliminary results of a multidisciplinary Italian study adopting a Psycho-Neuro-Endocrine-Immunological (PNEI) approach to the study of colorectal adenomas. Acta Biomed [Internet]. 2020 Sep. 30 [cited 2024 Jul. 24];92(1):e2021014. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10197