Covid-19 and the role of smoking: the protocol of the multicentric prospective study COSMO-IT (COvid19 and SMOking in ITaly).

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Maria Sofia Cattaruzza https://orcid.org/0000-0002-7489-3564
Giuseppe Gorini
Cristina Bosetti
Roberto Boffi
Alessandra Lugo
Chiara Veronese
Giulia Carreras
Claudia Santucci
Chiara Stival
Roberta Pacifici
Vincenzo Zagà
Silvano Gallus
Federico Giulietti
Riccardo Sarzani
Francesco Spannella
Mario Del Donno
Stefania Tartaglione
Giuseppina Marrazzo
Girolamo Pelaia
Vincenzo D'Agosto
Alice Berti
Fabio Voller
Salvatore Cardellicchio
Chiara Cresci
Maria Pia Foschino Barbaro
Raffaele De Palma
Simone Negrini
Vera Sicbaldi
Antonella Serafini
Mario Bisconti
Leonida Refolo
Giovanni Landoni
Patrizia Rovere
Giulia Veronesi
Paola Faverio
Werner Garavello
Alberto Pesci
Raffaella Giacobbe
Paola Martucci
Roberto Parrella
Francesco Scarano
Marina Aiello
Alfredo Chetta
Cosimo Franco
Angelo Mangia
Laura Carrozzi
Fabrizio Maggi
Fabio Monzani
Francesco Pistelli
Patrizia Russo
Antonio Sanna
Filippo Maria Barreca
Valentina Conti
Enrico Rossi
Mei Ruli
Silvana Ruli
Shokoofe Eslami Varzaneh
Rosastella Principe
Simone Guerrini
Alfredo Sebastiani
Giovanni Galluccio
Aldo Pezzuto
Alberto Ricci
Elena Casali
Claudio Mastroianni
Pietro Pirina
Francesca Polo
Fabio Beatrice
Micaela Romagnoli
Massimo Baraldo
Pier Giorgio Cojutti
Carlo Tascini
Davide Pecori
Elena Graziano
Biagio Tinghino

Keywords

COVID-19, lifestyle habits, prognosis, SARS-COV-2, smoking, tobacco, risk factors

Abstract

The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.

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