Neurological complications of COVID-19: from pathophysiology to rehabilitation. An overview.

Neurological complications of COVID-19: from pathophysiology to rehabilitation. An overview.


  • Loredana Raciti IRCCS Centro Neurolesi Bonino-Pulejo
  • Rocco Salvatore Calabrò IRCCS Centro Neurolesi "Bonino-Pulejo"


COVID-19; neurocovid; pandemic; neurological complications.


Objective: To evaluate how the SARS-COV2 is able to affect the nervous system, the main neurological manifestation, and the treatment used, including neurorehabilitation.

Methods: Studies performed during the current year that fulfilled inclusion criteria were selected from PubMed, Scopus, Cochrane, and Web of Sciences databases. The search combined the terms "Covid 19," "rehabilitation/treatment," and "neurological complications."

Results: The exact route by which SARS-CoV-2 can penetrate the CNS is still unknown, although a possible retrograde transynaptic pathway from peripheral nerve endings, and/or through the olfactory bulb, have been suggested. An early management of COVID-19 by a multiprofessional team is fundamental to avoid long term sequaele. Rehabilitation is recommended to improve respiratory and cardiac function, as well as to avoid long term neurological complications.

Conclusions: As no specific conclusions in term of prognosis and treatment could be done, research and consensus paper are needed to provide NeuroCovid patients with the best treatment options, including neurorehabilitation.


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How to Cite

Raciti L, Calabrò RS. Neurological complications of COVID-19: from pathophysiology to rehabilitation. An overview. Acta Biomed [Internet]. 2021 Sep. 2 [cited 2024 Jul. 24];92(4):e2021317. Available from: