Predictors of Clinical Outcomes in Adult COVID-19 Patients Admitted to a Tertiary Care Hospital in India: an analytical cross-sectional study: Predictors of clinical outcomes in COVID-19

Predictors of Clinical Outcomes in Adult COVID-19 Patients Admitted to a Tertiary Care Hospital in India: an analytical cross-sectional study

Predictors of clinical outcomes in COVID-19

Authors

  • Nishant Kumar Chauhan a:1:{s:5:"en_US";s:47:"All India Institute of Medical Sciences Jodhpur";}
  • Benhur Joel Shadrach Department of Pulmonary Medicine,All India Institute of Medical Sciences, Jodhpur
  • Mahendra Kumar Garg Department of General Medicine, All India Institute of Medical Sciences, Jodhpur
  • Pradeep Bhatia Department of Anaesthesiology and Critical care, All India Institute of Medical Sciences, Jodhpur
  • Pankaj Bhardwaj Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Jodhpur
  • Manoj Kumar Gupta Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Jodhpur
  • Naveen Dutt Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur
  • Ram Niwas Jalandra Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur
  • Pawan Garg Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur
  • Vijaya Lakshmi Nag Department of Microbiology, All India Institute of Medical Sciences, Jodhpur
  • Praveen Sharma Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur
  • Gopal Krishna Bohra Department of General Medicine, All India Institute of Medical Sciences, Jodhpur
  • Deepak Kumar Department of General Medicine, All India Institute of Medical Sciences, Jodhpur
  • Poonam Abhay Elhence Department of Pathology, All India Institute of Medical Sciences, Jodhpur
  • Mithu Banerjee Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur
  • Deepti Mathur Research assistant, All India Institute of Medical Sciences, Jodhpur
  • Abhishek HL Purohit Department of Pathology, All India Institute of Medical Sciences, Jodhpur
  • Ravisekhar Gadepalli Department of Microbiology, All India Institute of Medical Sciences, Jodhpur
  • Binit Sureka Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur
  • Sanjeev Misra Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur

Keywords:

COVID-19; D-dimer; Outcomes; Predictors; SOFA score

Abstract

Background:The outbreak ofsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted inexponential rise in the number of patients getting hospitalised with corona virus disease 2019 (COVID-19). There is a paucity of data from South East Asian Region related to the predictors of clinical outcomes in these patients. This formed the basis of conducting our study.

Methods:This was an analytical cross-sectional study. Demographic, clinical, radiological and laboratory data of 125 patients was collected on admission. The study outcome was death or discharge after recovery. For univariate analysis, unpaired t-test, Chi-square and Fisher’s Exact test were used. Receiver operating characteristic (ROC) curves were plotted for Sequential Organ Failure Assessment (SOFA) score and few laboratory parameters. Logistic regression was applied for multivariate analysis.

Results:Elderly age, ischemic heart disease and smoking were significantly associated with mortality. Elevated levels of D-dimer and lactate dehydrogenase (LDH) and reduced lymphocyte counts were the predictors of mortality. The ROCs for SOFA score curve showed a cut-off value ≥ 3.5 (sensitivity- 91.7% and specificity- 87.5%), for IL-6 the cut-off value was ≥ 37.9 (sensitivity- 96% and specificity- 78%) and for lymphocyte counts, a cut off was calculated to be less than and equal to 1.46 x 109per litre (sensitivity-75.2%and specificity- 83.3%).

Conclusion:Old age, smoking history, ischemic heart disease and laboratory parameters including elevated D-dimer, raised LDH and low lymphocyte counts at baseline are associated with COVID-19 mortality. A higher SOFA score at admission is a poor prognosticator in COVID-19 patients.

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Published

01-07-2021

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Section

ORIGINAL INVESTIGATIONS/COMMENTARIES - SPECIAL COVID19

How to Cite

1.
Chauhan NK, Shadrach BJ, Garg MK, Bhatia P, Bhardwaj P, Gupta MK, et al. Predictors of Clinical Outcomes in Adult COVID-19 Patients Admitted to a Tertiary Care Hospital in India: an analytical cross-sectional study: Predictors of clinical outcomes in COVID-19. Acta Biomed [Internet]. 2021 Jul. 1 [cited 2024 Jul. 24];92(3):e2021024. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10630