Study of a supplement and a genetic test for lymphedema management

Study of a supplement and a genetic test for lymphedema management

Authors

  • Sandro Michelini Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy
  • Marina Cestari Study Centre Pianeta Linfedema, Terni, Italy; Lymphology Sector of the Rehabilitation Service, USLUmbria2, Terni, Italy
  • Serena Michelini Unit of Physical Medicine and Rehabilitation, Sant‘Andrea Hospital, “Sapienza” University of Rome, Rome, Italy
  • Giorgio Camilleri EBTNA-LAB, Rovereto (TN), Italy
  • Luca De Antoni MAGI EUREGIO, Bolzano, Italy
  • Willy Nelson Sonna MAGI EUREGIO, Bolzano, Italy
  • Matteo Bertelli EBTNA-LAB, Rovereto (TN), Italy; MAGI EUREGIO, Bolzano, Italy; MAGI’S LAB, Rovereto (TN), Italy

Keywords:

lymphedema, hydroxytyrosol, leukotriene B4, food supplement

Abstract

Malformations in the lymphatic vasculature, injury, surgery, trauma or toxic damage may lead to swelling of the limbs caused by inefficient lymphatic uptake and flow (lymphedema). Lymphedema can be congenital or acquired. Primary lymphedema is rare and caused by mutations in single genes, secondary lymphedema is more common and caused by a trauma in association with a genetic predisposition. We decided to develop a genetic test that would determine the genetic predisposition to the onset of lymphedema and to predict the course of the disease by analyzing polymorphisms involved in leukotriene B4 (LTB4) synthetic pathway, and variants involved in the onset of secondary lymphedema. There are not many compounds available for the treatment of the negative effects of lymph accumulation, we therefore designed a food supplement based on the hydroxytyrosol, that has anti-oxidant, anti-bacterial and anti-inflammatory activities.

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Published

09-11-2020

How to Cite

1.
Michelini S, Cestari M, Michelini S, Camilleri G, De Antoni L, Sonna WN, et al. Study of a supplement and a genetic test for lymphedema management. Acta Biomed [Internet]. 2020 Nov. 9 [cited 2024 Oct. 4];91(13-S):e2020013. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10658