Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Main Article Content

Aysha Karim Kiani
Benedetto Falsini
Lucia Ziccardi
Elena Gusson
Domenica Mangialavori
Francesca Allegrini
Emma Colao
Matteo Bertelli

Keywords

Retinal degenerative disorders, neurotrophin synthesis, flavonoids supplementation, anti-inflammation, anti-oxidant

Abstract

Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and  dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.

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