Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases


  • Aysha Karim Kiani MAGI EUREGIO, Bolzano, Italy
  • Benedetto Falsini Department of Ophthalmology, Catholic University of Sacred Heart, Gemelli Policlinic, Rome, Italy
  • Lucia Ziccardi Fondazione Bietti-IRCCS, Rome, Italy
  • Elena Gusson Unit of Ophthalmology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
  • Domenica Mangialavori Institute of Ophthalmology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
  • Francesca Allegrini Eye Clinic, Department of Neurosciences, Biomedicine and Movement, University of Verona, Verona, Italy
  • Emma Colao Medical Genetics Unit, Magna Graecia University, Catanzaro, Italy
  • Matteo Bertelli MAGI EUREGIO, Bolzano, Italy; MAGI’S LAB, Rovereto (TN), Italy; EBTNA-LAB, Rovereto (TN), Italy


Retinal degenerative disorders, neurotrophin synthesis, flavonoids supplementation, anti-inflammation, anti-oxidant


Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and  dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.


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How to Cite

Kiani AK, Falsini B, Ziccardi L, Gusson E, Mangialavori D, Allegrini F, et al. Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases. Acta Biomed [Internet]. 2020 Nov. 9 [cited 2024 Jul. 19];91(13-S):e2020014. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10683