A rare sacral localization of giant cell tumor in a young adult female: a case report

A rare sacral localization of giant cell tumor in a young adult female: a case report

Authors

  • Umberto Tupputi Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, 71121 Foggia, Italy
  • Laura Eusebi Radiology Unit, “Carlo Urbani” Hospital, Jesi, Italy
  • Andrea Stronati Medicine Unit, Chiaravalle ASUR Marche Area Vasta 2, Loreto, Italy
  • Francesca Anna Carpagnano Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, 71121 Foggia, Italy
  • Valentina Testini Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, 71121 Foggia, Italy
  • Francesco Bartelli Radiology Unit, “Carlo Urbani” Hospital, Jesi, Italy
  • Giuseppe Guglielmi Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy; Radiology Unit, Barletta University Campus UNIFG, “Dimiccoli” Hospital, Italy

Keywords:

Giant cell tumor, musculoskeletal imaging, spine, computed tomography, magnetic resonance imaging

Abstract

We reported the case of a 42-years-old woman who suffered from a giant cell tumor of sacrum. Although the giant cell tumor primarily affects the long bones, especially those of the knee joint, it can rarely affect the axial skeleton and the sacrum.
The onset of symptoms is generally insidious and may include locoregional pain and swelling as well as movement deficits if nerve roots are involved at this level. In this case report we discuss on the radiographic imaging, computed tomography and magnetic resonance imaging features of this type of tumor in an unusual location of the disease.

Author Biography

Umberto Tupputi, Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, 71121 Foggia, Italy

Professor of Radiology, Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, 71121 Foggia, Italy

References

1. Cooper AS, Travers B. Surgical essays. London, England: Cox Longman & Co, 1818; 178–179.
2. Roitman PD, Jauk F, Farfalli GL, Albergo JI, Aponte-Tinao LA. Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls. Hum Pathol, 2017, 63:89–97.
3. Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA, Matcuk GR Jr. Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics, 2013, 33(1): 197–211.
4. Balke M, Schremper L, Gebert C, et al. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 2008;134(9):969–978.
5. Montgomery C, Couch C, Emory CL, Nicholas R. Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options. J Knee Surg. 2019;32(4):331-336.
6. Kwon JW, Chung HW, Cho EY, et al. MRI findings of giant cell tumors of the spine. AJR Am J Roent- genol 2007;189(1):246–250.
7. Qin LF, Peng D, Qin LH, Xu M, Fang H, Zhang Q. Huge giant cell tumor of the sacrum: A case report. Oncol Lett. 2014;7(3):894-896. doi:10.3892/ol.2014.1812
8. Murphey MD, Nomikos GC, Flemming DJ, Gan- non FH, Temple HT, Kransdorf MJ. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radio- Graphics 2001;21(5):1283–1309.
9. 5. Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am 2006;37(1):35–51.
10. 6. Arnold RT, van Holsbeeck MT, Mayer TG, Mott MP, Koch SR. Necrotic giant cell tumor of bone manifesting with pathologic fracture. RadioGraphics 2011;31(1):93–98.
11. Ji T, Yang Y, Wang Y, Sun K, Guo W. Combining of serial embolization and denosumab for large sacropelvic giant cell tumor: case report of 3 cases. Medicine (Baltimore), 2017, 96(33):e7799.
12. Wuisman P, Lieshout O, Sugihara S and van Dijk M: Total sacrectomy and reconstruction: oncologic and functional outcome. Clin Orthop Relat Res 381: 192-203, 2000.
13. Poll A, Nimigean VR, Vîrlan MJR, et al. A rare tumor in a rare location: giant cell tumor of the sacrum and ilium - case report and current perspectives. Rom J Morphol Embryol. 2019;60(3):985-992.
14. Martin C, McCarthy EF. Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J. 2010;30:69-75.
15. Randall RL. Giant cell tumor of the sacrum. Neurosurg Focus. 2003;15(2):E13. Published 2003 Aug 15. doi:10.3171/foc.2003.15.2.13
16. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013;21(2):118-126. doi:10.5435/JAAOS-21-02-118
17. Mavrogenis AF, Igoumenou VG, Megaloikonomos PD, Panagopoulos GN, Papagelopoulos PJ, Soucacos PN. Giant cell tumor of bone revisited. SICOT J. 2017;3:54. doi:10.1051/sicotj/2017041
18. van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H. Giant cell tumour of bone in the denosumab era. Eur J Cancer. 2017;77:75-83. doi:10.1016/j.ejca.2017.02.021

Downloads

Published

06-10-2021

Issue

Section

Case Reports: Oncology and Hematology

How to Cite

1.
Tupputi U, Eusebi L, Stronati A, Carpagnano FA, Testini V, Bartelli F, et al. A rare sacral localization of giant cell tumor in a young adult female: a case report. Acta Biomed [Internet]. 2021 Oct. 6 [cited 2024 Jul. 24];92(S1):e2021128. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10714