Cardio-protective effect of regular transfusion in children with non-transfusion dependent thalassemia (NTDT): A cohort study

Cardio-protective effect of regular transfusion in children with non-transfusion dependent thalassemia (NTDT): A cohort study

Authors

  • Khalfan Al Senaidi Sultan Qaboos University Hospital
  • Surekha Maveda Sultan Qaboos University Hospital
  • Niranjan Joshi Sultan Qaboos University Hospital
  • Hanan Nazir Faculty of Medicine, Alexandria University
  • Mohamed Elshinawy Faculty of Medicine, Alexandria University
  • Shoaib AL Zadjali Sultan Qaboos University Hospital
  • Abdulhakim Al Rawas Sultan Qaboos University Hospital
  • Islam Elghamry Sultan Qaboos University Hospital
  • Yasser Wali a:1:{s:5:"en_US";s:33:"Sultan Qaboos University Hospital";}
  • Doaa Khater Faculty of Medicine, Alexandria University

Keywords:

non-transfusion dependent thalassemia (NTDT), regular blood transfusion, echocardiography.

Abstract

Background and aim of the work:

 Cardiac complications occur in patients with non-transfusion dependent thalassemia (NTDT). The study aimed to evaluate transfusion effect on systolic and diastolic cardiac function in young NTDT patients. 

Methods: 

Study design: Cohort study.

Seventeen regularly-transfused patients with NTDT (12.5±5.3 years; group 1) and 15 none/minimally transfused patients (13.2±4.8 years; group 2) were followed up for 5 years and compared as regards their clinical parameters, echocardiographic and Tissue-Doppler-Imaging.

Results: Group 2 patients had significantly higher peak late-diastolic velocity of the left-ventricular-inflow Doppler (Am). Mitral-valve A-wave duration/pulmonary-veins, A-wave duration-ratio and pulmonary-vein S/D velocities-ratio were larger in group 2 as well (p = < 0.01). The diameters of right and left outflow-tract were larger with a higher cardiac-index in patients of group 2. Systolic-function was similar in the 2 studied groups.

Conclusion:

Diastolic function assessment revealed indicators of an abnormal relaxation of left-ventricle in non-transfused patients, which suggests a diastolic dysfunction. An increase in the diameter of the outflow-tract is likely attributed to high cardiac-output status in non-transfused NTDT patients as they have a higher cardiac index. Early start of regular transfusion for NTDT patients might prevent serious long-term cardiac complications.

Author Biographies

Khalfan Al Senaidi, Sultan Qaboos University Hospital

Child Health Department, Sultan Qaboos University Hospital, Oman;

Surekha Maveda, Sultan Qaboos University Hospital

Child Health Department, Sultan Qaboos University Hospital, Oman

Niranjan Joshi, Sultan Qaboos University Hospital

Child Health Department, Sultan Qaboos University Hospital, Oman

Hanan Nazir , Faculty of Medicine, Alexandria University

Department of Pediatrics

Mohamed Elshinawy, Faculty of Medicine, Alexandria University

Department of Pediatrics

Shoaib AL Zadjali , Sultan Qaboos University Hospital

Department of Hematology

Abdulhakim Al Rawas , Sultan Qaboos University Hospital

Child Health Department

Islam Elghamry , Sultan Qaboos University Hospital

Child Health Department, Sultan Qaboos University Hospital, Oman

Doaa Khater, Faculty of Medicine, Alexandria University

Department of Pediatrics

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Published

11-05-2022

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ORIGINAL ARTICLES

How to Cite

1.
Al Senaidi K, Maveda S, Joshi N, Nazir H, Elshinawy M, AL Zadjali S, et al. Cardio-protective effect of regular transfusion in children with non-transfusion dependent thalassemia (NTDT): A cohort study . Acta Biomed [Internet]. 2022 May 11 [cited 2024 Jul. 12];93(2):e2022022. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/10736