Comparison of stent and indomethacin suppository efficacy in the prevention of acute pancreatitis after ERCP

Comparison of stent and indomethacin suppository efficacy in the prevention of acute pancreatitis after ERCP


  • Gamze Icacan Fırat University, Deparment of Nephrology, Faculty of Medicine, Elazığ,Turkey
  • Erhan Onalan Department of Internal Medicine, Faculty of Medicine, Firat Univeristy, 23000, Elazig, Turkey
  • Mehmet Yucesoy Erciyes University, Deparment of Internal Medicine, Faculty of Medicine, Kayseri,Turkey


Endoscopic retrograde cholangiopancretiography, post-ERCP pancreatitis, non-steroidal anti-inflammatory drug, ındomethacin


Objective: We aimed to compare stent and indomethacin suppository efficacy in the prevention of acute pancreatitis after ERCP.

Materials and Methods: 76 high-risk patients undergoing ERCP were included in the study. The patients were divided into three groups as indomethacin group, stent group and control group. Indomethacin group (n = 32) received 100 mg rectal indomethacin immediately after ERCP. A 5F pancreatic stent was applied to the stent group (n = 16) during ERCP. No prophylaxis was given to the control group (n = 28).

Results: There was no difference between the groups in terms of age and gender. ERCP pancreatitis was seen in 9.2% (7/76) of the patients. The incidence of ERCP-induced pancreatitis (PEP) was 3.1% (1/32) in the indomethacin group and 21.4% (6/28) in the control group. PEP was not seen in the stent group (0/16). The incidence of PEP was significantly lower in the indomethacin group than in the control group (p = 0.043). However, no significant difference was found between the stent and control groups, stent and indomethacin groups in terms of PEP frequency (p = 0.072, p: 0.90 respectively).

Conclusion: According to the results of our study, rectal indomethacin administration decreased the frequency of PEP in high-risk patients. However, there was no significant difference in PEP prophylaxis between the stent and indomethacin groups.


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How to Cite

Icacan G, Onalan E, Yucesoy M. Comparison of stent and indomethacin suppository efficacy in the prevention of acute pancreatitis after ERCP. Acta Biomed [Internet]. 2021 Sep. 2 [cited 2024 Jul. 24];92(4):e2021178. Available from: