COVID-19 in transplant recipient children: An Iranian referral hospital-based study

COVID-19 in transplant recipient children: An Iranian referral hospital-based study

Authors

  • Golnaz Ghazizadeh Esslami Tehran University of Medical Sciences
  • Setareh Mamishi a:1:{s:5:"en_US";s:37:"Tehran University of Medical sciences";}
  • Shima Mahmoudi Tehran University of Medical Sciences
  • Amene Navaeian Tehran University of Medical Sciences
  • Maryam Behfar Tehran University of Medical Sciences
  • Amir Ali Hamidieh Tehran University of Medical Sciences
  • Hosein Alimadadi Tehran University of Medical Sciences
  • Yasmine Mahmoudieh 7- Department of Molecular and Cell Biology, University of California, Berkeley

Keywords:

COVID-19, SARS-CoV-2, immunocompromised, transplant, children

Abstract

To our knowledge, there is still very limited information on the severity, mortality, laboratory, and radiologic findings of COVID‐19 infection in transplant patients, particularly children. In this study, we report and analyze 7 transplant recipients with laboratory‐confirmed COVID‐19 infection. The median age was 7.5 years (IQR: 31month-10 years), and 71% of the patients were male. All cases presented with a fever. The median duration of fever before admission was 2 days (IQR:1-8 days). Five patients (71%) experienced cough and dyspnea. Lymphocytopenia (Median of 0.6 (IQR: 0.14-2.0× 10⁹ cells per L) and thrombocytopenia (Median of 65 (IQR: 49-201× 10⁹ cells per L) were the most common CBC findings (both seen in 5 out of the 7 patients. Among 4 of the patients who underwent CT scans, 2 had ground glass opacity and consolidations. The mean number of lobe involvement in our patients was 3(0-5), and 75% of the cases showed bilateral lung involvement in the imaging. In 4 patients (51%) the disease course manifested severely, and 2 patients are now deceased (28.6%). In conclusion, immunocompromised pediatric subgroups may experience higher rates of disease severity and mortality in comparison with the immunocompetent pediatric population.

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Published

12-05-2021

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ORIGINAL INVESTIGATIONS/COMMENTARIES - SPECIAL COVID19

How to Cite

1.
COVID-19 in transplant recipient children: An Iranian referral hospital-based study. Acta Biomed [Internet]. 2021 May 12 [cited 2024 Mar. 29];92(2):e2021095. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/11189