Intravenous treatment with biphosphates in Complex Regional Pain Syndrome.

Intravenous treatment with biphosphates in Complex Regional Pain Syndrome.


  • Marianna Faggiani Department of Orthopaedic Surgery and Traumatology. “Maggiore” Hospital of Chieri. Turin. Italy
  • Alice Piccato Department of Orthopaedic Surgery and traumatology. “Edoardo Agnelli” Hospital – Pinerolo. Italy
  • Chiara Baroni Department of Orthopaedic Surgery and Traumatology. “Maggiore” Hospital of Chieri. Turin. Italy
  • Salvatore Risitano Department of Orthopaedic Surgery and Traumatology. “Maggiore” Hospital of Chieri. Turin. Italy
  • Luigi Giulio Conforti Department of Orthopaedic Surgery and Traumatology. “Maggiore” Hospital of Chieri. Turin. Italy


Complex Regional Pain Syndrome, intravenous biphosphates.


Background. Complex Regional Pain Syndrome (CRPS) is a pathological persistence of spontaneous or evoked disproportionate pain. Several drugs are employed, but only bisphosphonates seem to have good outcomes. The purpose of our research is to analyze the characteristics of the cases victims of CRPS and study the beneficial effect of the intravenous nerindronic acid sodium salt (Nerixia®), in an attempt to improve the results in this disabling disease. Materials and methods: We retrospectively examined 30 cases of CRPS that had undergone intravenous nerindronic acid sodium salt therapy in our center. The patients were contacted after 12 months from the start of therapy and their clinical situation was assessed with Quick DASH Score. Results: The average age of our group was 59,76 years (span, 42–78), and female subjects were 84% (p-value <0.05). 72% of all cases were complications of wrist fractures.). The Quick DASH Score (19 points are the best result, 95 the worst outcome) average was 41,1 points. The values of Quick DASH Score differed significantly (p-value <0.001) according to the age of the patient. In addition, the DASH Score values were related to the sex of the patient (p-value <0.001). Male subjects have obtained a better score. After 12 months of intravenous therapy, 52% of cases reports that they still have joint stiffness. The DASH values differed significantly depending on the onset of intravenous treatment (p-value <0.001). Conclusion: Our study showed that the CRPS affects a population between 42 and 78 years, especially women. Treatment with intravenous bisphosphonates seems to lead to an improvement in CRPS symptoms, in particular administration between 3 and 6 months after the onset of the disease. In particular, women over 61 years of age seem to have a lower improvement in symptomatology after treatment. 52% of cases report that they still have joint stiffness.


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How to Cite

Faggiani M, Piccato A, Baroni C, Risitano S, Conforti LG. Intravenous treatment with biphosphates in Complex Regional Pain Syndrome. Acta Biomed [Internet]. 2021 Sep. 2 [cited 2024 Jul. 23];92(4):e2021190. Available from: