Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19

Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19


  • Brandon Henry a:1:{s:5:"en_US";s:45:"Cincinnati Children's Hospital Medical Center";}
  • Stefanie Benoit Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, OH, USA
  • Jens Vikse Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
  • Emmanuel Favaloro Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead NSW, Australia
  • Justin Benoit Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
  • Giuseppe Lippi Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy


SARS-CoV-2, auto-antibodies, coagulopathy




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[2] Henry BM, Vikse J, Benoit S, et al. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clinica Chimica Acta. 2020;507:167–173.
[3] Zhang Y, Xiao M, Zhang S, et al. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med 2020;382:e38.
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[6] Galeano-Valle F, Oblitas CM, Ferreiro-Mazón MM, et al. Antiphospholipid antibodies are not elevated in patients with severe COVID-19 pneumonia and venous thromboembolism. Thromb Res. 2020;192:113–115.
[7] Alessandri C, Bombardieri M, Valesini G. Pathogenic mechanisms of anti-endothelial cell antibodies (AECA): their prevalence and clinical relevance. Adv Clin Chem. 2006;42:297–326.
[8] Praprotnik S, Blank M, Meroni PL, et al. Classification of anti–endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications. Arthritis & Rheumatism. 2001;44:1484–1494.
[9] Yang Y, Huang Y, Chuang Y, et al. Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome (SARS)‐associated coronavirus infection. J Med Virol. 2005;77:1–7.
[10] Belizna C, Duijvestijn A, Hamidou M, et al. Antiendothelial cell antibodies in vasculitis and connective tissue disease. Ann Rheum Dis. 2006;65:1545–1550.







How to Cite

Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19. Acta Biomed [Internet]. 2022 May 11 [cited 2024 Jun. 15];93(2):e2022043. Available from:

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