Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19.: Phlegmasia and disseminated intravascular coagulation in COVID-19.

Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19.

Phlegmasia and disseminated intravascular coagulation in COVID-19.


  • Daniele Orso University of Udine
  • Lisa Mattuzzi University of Udine
  • Sara Scapol University of Udine
  • Silvia Delrio University of Udine
  • Luigi Vetrugno University of Udine
  • Tiziana Bove University of Udine


Phlegmasia cerulea dolens; disseminated intravascular coagulation; COVI-19.


COVID-19 infection has several cardiovascular implications, and coagulopathy is a common abnormality in these patients, often coupled with elevated plasma fibrinogen and D-dimer levels, contributing to adverse outcomes. Phlegmasia cerulea dolens (PCD) is a rare manifestation of deep vein thrombosis. It is life-threatening and can rapidly lead to venous gangrene of the extremity. Only a few cases of COVID-19 associated with PCD are reported in the literature, despite thromboembolism being the common paradigm between the two diseases. We present the case of a 64-year-old adult with acute severe COVID-19 pneumonia who developed PCD despite constantly elevated activated partial thromboplastin time and international normalized ratio.


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How to Cite

Orso D, Mattuzzi L, Scapol S, Delrio S, Vetrugno L, Bove T. Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19.: Phlegmasia and disseminated intravascular coagulation in COVID-19. Acta Biomed [Internet]. 2021 Sep. 2 [cited 2024 Jul. 24];92(4):e2021101. Available from: