Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19.: Phlegmasia and disseminated intravascular coagulation in COVID-19.

Daniele Orso; Lisa Mattuzzi; Sara Scapol; Silvia Delrio; Luigi Vetrugno; Tiziana Bove

doi:10.23750/abm.v92i4.11478

Phlegmasia cerulea dolens superimposed on disseminated intravascular coagulation in COVID-19.

Phlegmasia and disseminated intravascular coagulation in COVID-19.

Authors

Daniele Orso University of Udine
Lisa Mattuzzi University of Udine
Sara Scapol University of Udine
Silvia Delrio University of Udine
Luigi Vetrugno University of Udine
Tiziana Bove University of Udine

DOI: https://doi.org/10.23750/abm.v92i4.11478

Keywords:

Phlegmasia cerulea dolens; disseminated intravascular coagulation; COVI-19.

Abstract

COVID-19 infection has several cardiovascular implications, and coagulopathy is a common abnormality in these patients, often coupled with elevated plasma fibrinogen and D-dimer levels, contributing to adverse outcomes. Phlegmasia cerulea dolens (PCD) is a rare manifestation of deep vein thrombosis. It is life-threatening and can rapidly lead to venous gangrene of the extremity. Only a few cases of COVID-19 associated with PCD are reported in the literature, despite thromboembolism being the common paradigm between the two diseases. We present the case of a 64-year-old adult with acute severe COVID-19 pneumonia who developed PCD despite constantly elevated activated partial thromboplastin time and international normalized ratio.

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