Peripherally Inserted Central Venous Catheters (PICC) versus totally implantable venous access device (PORT) for chemotherapy administration: a meta-analysis on gynecological cancer patients

Peripherally Inserted Central Venous Catheters (PICC) versus totally implantable venous access device (PORT) for chemotherapy administration: a meta-analysis on gynecological cancer patients

Authors

  • Vito Andrea Capozzi Department of medicine and surgery, University of Parma.
  • Luciano Monfardini Department of medicine and surgery, University of Parma.
  • Giulio Sozzi Department of gynecologic oncology, University of Palermo.
  • Giulia Armano Department of medicine and surgery, University of Parma.
  • Diana Butera Department of medicine and surgery, University of Parma.
  • Elisa Scarpelli Department of medicine and surgery, University of Parma.
  • Giuseppe Barresi Department of medicine and surgery, University of Parma.
  • Alessandro Benegiamo Department of medicine and surgery, University of Parma.
  • Roberto Berretta Department of medicine and surgery, University of Parma.

Keywords:

Gynecological cancer, Meta-analysis., Central venous catheter, PORT, Peripherally inserted central venous catheters

Abstract

Background and aim: Ninety-four thousand gynecological cancer diagnoses are performed each year in the United States. The majority of these tumors require systemic adjuvant therapy. Sustained venous access was overcome by indwelling long-term central venous catheter (CVC). The best choice of which CVC to use is often arbitrary or dependent on physician confidence. This meta-analysis aims to compare PORT and peripherally inserted central catheter (PICC) outcomes during adjuvant treatment for gynecological cancer.

Methods: Meta-analysis Of Observational Studies in Epidemiology (MOOSE) and the preferred reporting items for systematic reviews and meta-analyses statement (PRISMA)were used to conduct the meta-analysis.

Results: 1320 patients were included, 794 belonging to the PORT group and 526 to the PICC group. Total complication rates were fewer in the PORT group, p = 0.05. CVC malfunction was less frequent in the PORT group than in the PICC group, p <0.01. Finally, thrombotic events were less expressed in the PORT group than in the PICC group, p = 0.02. No difference was found in operative complication, migration, malposition, extravasation, infection, and complication requiring catheter removal.

Conclusions: PORT had fewer thrombotic complications and fewer malfunction problems than PICC devices. Unless specific contraindications, PORTs can be preferred for systemic treatment in gynecological cancer patients.

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03-11-2021

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1.
Capozzi VA, Monfardini L, Sozzi G, Armano G, Butera D, Scarpelli E, et al. Peripherally Inserted Central Venous Catheters (PICC) versus totally implantable venous access device (PORT) for chemotherapy administration: a meta-analysis on gynecological cancer patients. Acta Biomed [Internet]. 2021 Nov. 3 [cited 2024 Jul. 21];92(5):e2021257. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/11844