Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness

Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness

Authors

  • Samar Magboul Hamad Medical Corporation, Academic General Pediatric Department, Doha (Qatar)
  • Ahmed Khalil Hamad Medical Corporation, Clinical Pharmacy Department, Doha (Qatar)
  • Manasik Hassan Hamad Medical Corporation, Academic General Pediatric Department, Doha (Qatar) and Weill Cornell Medical College, Clinical Pediatric Department, Doha (Qatar)
  • Basel Habra Hamad Medical Corporation, Pediatric Pulmonology, Doha (Qatar)
  • Ahmad Alshami Hamad Medical Corporation, Pediatric Emergency Department, Doha (Qatar) and Weill Cornell Medical College, Clinical Pediatric Department, Doha (Qatar)
  • Shabina Khan Hamad Medical Corporation, Academic General Pediatric Department, Doha (Qatar)
  • Khaled Ellithy Hamad Medical corporation, Pediatric Intensive Care Unit, Doha (Qatar)
  • Hossamaldein Ali Hamad Medical Corporation, Clinical Pharmacy Department, Doha (Qatar)
  • Abdulla AlHothi Weill Cornell Medical College, Clinical Pediatric Department, Doha (Qatar)
  • Eman AlMaslamani Sidra Medicine, Pediatric Infectious Diseases Department, Doha (Qatar)
  • Mohamed AlAmri Hamad Medical Corporation, Pediatric Emergency Department, Doha (Qatar)
  • Vincenzo De Sanctis Quisisana Hospital, Ferrara
  • Ashraf T Soliman Hamad Medical Corporation, Pediatric Endocrinology Department, Doha (Qatar)

Keywords:

SARS-CoV-2 infection, Multisystem Inflammatory Syndrome (MIS-C), infants, children, treatment, Qatar.

Abstract

Introduction: World Health Organization (WHO) is encouraging reporting of children with Multisystem Inflammatory Syndrome (MIS-C) associated with SARS-CoV-2 infection for better understanding and management of the disease. Methodology: This retrospective study included the first 15 pediatrics patient with a confirmed diagnosis of MIS-C associated with SARS-CoV-2 infection in the state of Qatar. We studied and analyzed their demographic data, clinical manifestations, laboratory tests, treatment, and outcome. Results: A total of 15 children were studied (mean age 3.5 ± 2.7year). Recent severe acute respiratory syndrome coronavirus 2 infection was identified in all of them (100%). The majority of these patients had 4 or more systems involvement. Nine of the 15 presented with Kawasaki disease - picture and all had gastrointestinal symptoms (vomiting and diarrhea). Five required Pediatrics Intensive Care Unit (PICU) admission. Lab investigations revealed high D-Dimer, hyponatremia, and hypoalbuminemia in all. Low hemoglobin (Hb) , thrombocytopenia, and sterile pyuria occurred in 86.6%, 60% and 75% of them, respectively. Treatment with combined anti-inflammatory medications (intravenous immunoglobulin, corticosteroids) was used in along with immunomodulatory agents (Anakinra) in a selected group of refractory patients. No mortality happened.Conclusion: Our young children who presented with MIS-C related to SARS-CoV-2 infection had significantly higher Kawasaki-disease picture compared to other reports. One third of them required PICU admission but no mortality occurred.

References

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Published

19-01-2022

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Section

ORIGINAL INVESTIGATIONS/COMMENTARIES - SPECIAL COVID19

How to Cite

1.
Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness . Acta Biomed [Internet]. 2022 Jan. 19 [cited 2024 Jun. 19];92(6):e2021543. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/11991

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