HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.

HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.


  • Giorgio Ciprandi Consultant Allergist, Casa di Cura Villa Montallegro, Genoa, Italy
  • Luisa Maria Bellussi International Federation ORL Societies (IFOS) Executive Board members Rome Italy
  • Valerio Damiani Medical Department, DMG Italia, Rome, Italy.
  • Desiderio Passali International Federation ORL Societies (IFOS) Executive Board members Rome Italy


COVID-19, SARS CoV-2, HMGB1, Glycyrrhizin, Prophylaxis.


The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in pathogenic mechanisms induced by SARS-CoV-2.  As HMGB1 is antagonized by glycyrrhizin, this substance could be potentially useful as ancillary treatment in COVID-19.


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How to Cite

Ciprandi G, Bellussi LM, Damiani V, Passali D. HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19. . Acta Biomed [Internet]. 2021 Oct. 1 [cited 2024 Jul. 24];92(S6):e2021455. Available from: