Peripheral Arterial Tonometry (EndoPAT)-measured Endothelial Dysfunction in Migraine with Aura children

Peripheral Arterial Tonometry (EndoPAT)-measured Endothelial Dysfunction in Migraine with Aura children

Authors

  • Alice Bonuccelli Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Claudia Sciarrotta Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Maria Grazia Esposito Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Vanessa Bianchi Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Mario Miccoli Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  • Pasquale Striano Pediatric Neurology Unit, Dinogmi, Giannina Gaslini’s. Istitute, University of Genoa
  • Riccardo D'angelo Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Margherita Valiani Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa
  • Emioli Randazzo Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy
  • Thomas Foiadelli Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
  • Diego Peroni Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy
  • Giovanni Federico Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy
  • Alessandro Orsini Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy

Keywords:

Migraine with aura, endothelial dysfunction, EndoPAT, arterial stiffness

Abstract

Background. The association between Migraine with Aura (MA) and vascular disease has been previously reported. We investigated whether pre-clinical vascular alterations, such as Endothelial Dysfunction, are already present in children and adolescents with Migraine with Aura.

Methods. We retrospectively enrolled 27 patients having Migraine with Aura, aged9 -18 years, and 31 age matched healthy control subjects to evaluateEndothelial Function by Peripheral Arterial Tonometry. This technique measures finger pulse wave amplitude, before and during reactive hyperaemia, and calculates the Augmentation Index (AI) and the Reactive Hyperaemia Index (RHI). We also set-up an Aura Severity Scale to assess disease severity and its relationship with AI and RHI alterations.

Results. Also if the case-control study resulted only partially as significant, we found there is an inversely proportional relationship between the severity of the migraine measured with Aura Severity Scale and the values of the endoscore (a significantly reduced levels of AI (p-value <0,03) and a marginal reduction of RHI levels (p-value <0,07).

Conclusion. Further studies should explore the impact of pre-clinical vascular alterations in children and adolescents with Migraine with Aura.

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Published

21-03-2022

How to Cite

1.
Peripheral Arterial Tonometry (EndoPAT)-measured Endothelial Dysfunction in Migraine with Aura children . Acta Biomed [Internet]. 2022 Mar. 21 [cited 2024 Apr. 24];92(S4):e2021345. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/12674

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