Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine

Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine


  • Igor Kaidashev Poltava State Medical University, Poltava
  • Anna Lavrenko Poltava State Medical University, Poltava
  • Tatiana Baranovskaya Kyiv City Clinical Hospital №17, Department of Clinical Pulmonology, Kyiv
  • Victor Blazhko Municipal non-profit enterprise “City Clinical Hospital №13” of Kharkiv City Council, Pulmonology department №2, Kharkiv
  • Nataliia Digtiar Poltava State Medical University, Poltava
  • Oleksandr Dziublyk
  • Nataliia Gerasymenko Poltava State Medical University, Poltava
  • Liudmyla Iashyna State Institution “National Institute of Tuberculosis and Pulmonology. F.G. Yanovsky National Academy of Medical Sciences of Ukraine”, Kyiv
  • Volodymyr Kryvetskyi National Pirogov Memorial Medical University, Vinnytsia
  • Lesya Kuryk State Institution “National Institute of Tuberculosis and Pulmonology. F.G. Yanovsky National Academy of Medical Sciences of Ukraine”, Kyiv
  • Victoria Rodionova Dnipropetrovsk State Medical Academy, Dnipro
  • Roman Stets Municipal institution “6th city clinical hospital”, Zaporizhzhia
  • Ivan Vyshnyvetskyy Bogomolets National Medical University, Kyiv; Municipal Institution Central City Hospital №1, Zhytomyr
  • Yurii Feshchenko State Institution “National Institute of Tuberculosis and Pulmonology. F.G. Yanovsky National Academy of Medical Sciences of Ukraine”, Kyiv


antibiotics, delafloxacin, empiric antimicrobial therapy, moxifloxacin, community-acquired pneumonia


Background and aim: Empiric therapy of community-acquired pneumonia (CAP) remains the standard care and guidelines are mostly based on published data from the United States or Europe. In this study, we determined the bacterial etiology of CAP and evaluated the clinical outcomes under antimicrobial treatment of CAP in Ukraine.

Methods: A total of 98 adult subjects with CAP and PORT risk II-IV were recruited for the study. The sputum diagnostic samples were obtained from all patients for causative pathogen identification. Subjects were randomly assigned in a 1:1 ratio to receive delafloxacin 300 mg (n=51) or moxifloxacin 400 mg (n=47) with blinding placebo. The switch to oral treatment was after a minimum of 6 IV doses according to clinical criteria. The total duration of antibacterial treatment was 5-10 days. In vitro susceptibility of pathogens to delafloxacin and other comparator antibiotics was determined.

Results: The most frequently isolated pathogens in adults with CAP were S. pneumoniae – 19.5%, M. pneumoniae – 15.3%, H. influenzae – 13.2%, S. aureus – 10.5%, K. pneumoniae – 10.1%, and H. parainfluenzae – 6.4%. All isolates of S. pneumoniae, S. aureus, M. pneumoniae had sufficient susceptibility to appropriate antibiotics. 9.0% of H. influenzae strains were susceptible to azithromycin. 94.8 % of patients had a successful clinical response to delafloxacin at the end of treatment and 93.9 % – at test-of-cure.

Conclusions: In Ukraine, the major bacterial agents that induced CAP in adults were S. pneumoniae, M. pneumoniae, H. influenzae, S. aureus, K. pneumoniae, H. parainfluenzae, E. cloacae, L. pneumophila. Delafloxacin is a promising effective antibiotic for monotherapy for CAP in adults and could be used in cases of antimicrobial-resistant strains.


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How to Cite

Kaidashev I, Lavrenko A, Baranovskaya T, Blazhko V, Digtiar N, Dziublyk O, et al. Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine. Acta Biomed [Internet]. 2022 May 11 [cited 2024 Jul. 13];93(2):e2022238. Available from: