Association between perceptions of antiretroviral drug use and medication adherence in patients with human immunodeficiency virus

Association between perceptions of antiretroviral drug use and medication adherence in patients with human immunodeficiency virus

Authors

  • Muthmainnah Department of Internal Medicine, Faculty of Medicine, Hasanuddin University
  • Sudirman Katu Division of Tropical Infection, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University
  • Nur Ahmad Tabri Division of Pulmonology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University
  • Saidah Syamsuddin Department of Psychiatry, Faculty of Medicine, Hasanuddin University
  • Syakib Bakri Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University
  • Arifin Seweng Department of Biostatistic, Faculty of Public Health, Hasanuddin University

Keywords:

Perception, Antiretroviral therapy, Adherence, Beliefs about Medicines Questionnaire

Abstract

Background and aim: The effectiveness of antiretroviral therapy (ART) is determined by both antiretroviral (ARV) drugs and patient adherence. Positive perceptions of ART among people living with HIV and AIDS (PLHIVs) are crucial for maintaining good adherence; thus, negative beliefs about ARV drugs can result in lower ART effectiveness. This study analyzed the association between perceptions of ARV drug use and other medication adherence factors in patients with HIV. Methods: This observational, cross-sectional study included 102 PLHIVs to retrospectively assess adherence to ART through self-reports of patients while they were receiving ART. Perceptions of ARV drug use were evaluated with the Beliefs about Medicines Questionnaire. Statistical analysis was performed with the chi-square test, independent t-test, and Mann-Whitney test. Statistical significance was described as a p-value of <0.05. Results: Most participants (86.3%) exhibited good adherence. Participants with good adherence had stronger beliefs and positive perceptions about the benefits of ART (p = 0.915). They also had lower perceptions about the potential adverse effects of ARV drugs than participants with moderate or low adherence (p = 0.608). A CD4 T-cell count ³ 200 cells/mm3 was significantly associated with medication adherence (p < 0.001), but no other significant associations were observed between sociodemographic/other factors (i.e., side effects of ARV drugs, duration of ART, and number of ARV tablets) and medication adherence. Conclusions: Perceptions of ARV drugs were not significantly associated with medication adherence in patients with HIV. The only significant influencing factor was a CD4 T-cell count of ³200 cells/mm3

References

Al-Mozaini M, Al-Rahabani T, Dirar Q, et al. Human immunodeficiency virus in Saudi Arabia: current and future challenges. J Infect Public Health. 2023;16(9):1500-9. doi:10.1016/j.jiph.2023.06.012.

Santoso APA, Habib M, Kresna Agung Yudhianto, Lestari TI. Hak Reproduksi pada Penderita HIV/AIDS Ditinjau dari Sudut Pandang Hukum dan Agama. J Ilmu Sos Pendidik. 2023;7(3):2004-17. doi:10.58258/jisip.v7i1.5130/http.

Sianturi EI, Gunawan E, Perwitasari DA. Adaptation and validation of the beliefs about medicines questionnaire (BMQ) in HIV out-patients in Indonesia. J Manaj Pel Farm 2021;11(3):173. doi:10.22146/jmpf.65032.

Dagli-Hernandez C, Lucchetta RC, de Nadai TR, Galduroz JCF, Mastroianni PC. Self-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapy. Patient Prefer Adherence. 2016;10:1787-93. doi:10.2147/PPA.S112108.

Sawitri AAS, Sutarsa IN, Merati TP, Bakta M, Wirawan DN. Perceptions dynamics about antiretroviral treatment among HIV patients in Bali. Int J Public Heal Sci. 2021;10(3):500. doi:10.11591/ijphs.v10i3.20917.

Lessard D, Toupin I, Engler K, Lenart A, Lebouche B. HIV-positive patients’ perceptions of antiretroviral therapy adherence in relation to subjective time: imprinting, domino effects, and future shadowing. J Int Assoc Provid AIDS Care. 2018;17:2325958218759208. doi:10.1177/2325958218759208.

Croome N, Potter L, Bere T, et al. Medication beliefs among people living with HIV taking antiretroviral treatment in Zimbabwe: a qualitative study. J Glob Heal Reports. 2020;4. doi:10.29392/001c.18083.

Schonnesson LN, Williams ML, Ross MW, Diamond PM, Keel B. Three types of adherence to HIV antiretroviral therapy and their association with AIDS diagnosis, medication side-effects, beliefs about antiretroviral therapy, and beliefs about HIV disease. Int J STD AIDS. 2007;18(6):369-73. doi:10.1258/095646207781024757.

Horne R, Cooper V, Gellaitry G, Date HL, Fisher M. Patients’ perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: the utility of the necessity-concerns framework. J Acquir Immune Defic Syndr. 2007;45(3):334-41. doi:10.1097/QAI.0b013e31806910e3.

Adefolalu A, Nkosi Z, Olorunju S, Masemola P. Self-efficacy, medication beliefs and adherence to antiretroviral therapy by patients attending a health facility in Pretoria. South African Fam Pract. 2014;56(5):281-5. doi:10.1080/20786190.2014.975476.

Kamal S, Bugnon O, Cavassini M, Schneider MP. HIV-infected patients’ beliefs about their chronic co-treatments in comparison with their combined antiretroviral therapy. HIV Med. 2018;19(1):49-58. doi:10.1111/hiv.12542.

Adefolalu AO, Nkosi ZZ. The complex nature of adherence in the management of HIV/AIDS as a chronic medical condition. Diseases. 2013;1(1):18-35. doi:10.3390/diseases1010018.

Komninis ID, Micheli K, Roumeliotaki T, Horne R. Adaptation and validation of the Beliefs about Medicines Questionnaire (BMQ) in primary care patients in Greece. Eur J Pers Centered Healthc. 2013;1(1):224. doi:10.5750/ejpch.v1i1.655.

Fall E, Gauchet A, Izaute M, Horne R, Chakroun N. Validation of the French version of the Beliefs about Medicines Questionnaire (BMQ) among diabetes and HIV patients. Eur Rev Appl Psychol. 2014;64(6):335-43. doi:10.1016/j.erap.2014.08.005.

Glendinning E, Spiers J, Smith JA, et al. A qualitative study to identify perceptual barriers to antiretroviral therapy (ART) uptake and adherence in HIV positive people from UK Black African and Caribbean communities. AIDS Behav. 2019;23(9):2514-21. doi:10.1007/s10461-019-02670-x.

Rivero-Méndez M, Dawson-Rose CS, Solís-Báez SS. A Qualitative Study of Providers' Perception of Adherence of Women Living with HIV/AIDS in Puerto Rico. Qual Rep. 2010;15(2):232-51. PMID: 21243076.

Alhewiti A. Adherence to long-term therapies and beliefs about medications. Int J Family Med. 2014;2014:479596. doi:10.1155/2014/479596.

International Labour Organization. The Impact of Employment on HIV Treatment Adherence. 2013.

Supriyatni N, Salim LA, Hargono A, Febriyanti F. Antiretroviral medication adherence for people with HIV/AIDS. J Public Health Africa. Published online May 30, 2023. doi:10.4081/jphia.2023.2434.

Debby C, Sianturi SR, Susilo WH. Factors related to compliance of ARV medication in HIV patients at RSCM Jakarta. J Keperawatan. 2019;10(1):15-22. doi:10.22219/jk.v10i1.5886.

Sari YK, Nurmawati T, Putri Hidayat A. Analisis Faktor Yang Mempengaruhi Kepatuhan Pasien HIV-AIDS Dalam Terapi Antiteroviral (ARV). J Citra Keperawatan. 2019;7(2):96-103. doi:10.31964/jck.v7i2.116.

McDonald S. Young people and self-reported adherence to antiretroviral therapy: a HYPNet survey. In: 17th Annual British HIV Association Conference; 2011:198.

Achappa B, Madi D, Bhaskaran U, Ramapuram JT, Rao S, Mahalingam S. Adherence to antiretroviral therapy among people living with HIV. N Am J Med Sci. 2013;5(3):220-3. doi:10.4103/1947-2714.109196.

Zhang L, Li X, Lin Z, et al. Side effects, adherence self-efficacy, and adherence to antiretroviral treatment: a mediation analysis in a Chinese sample. AIDS Care. 2016;28(7):919-26. doi:10.1080/09540121.2015.1124984.

Dorcélus L, Bernard JJ, Georgery C, Vanessa C. Factors associated with antiretroviral therapy adherence among people living with HIV in Haiti: a cross-sectional study. AIDS Res Ther. 2021;18(1):81. doi:10.1186/s12981-021-00405-4.

Martiana I, Waluyo A, Yona S. Assessing the relationship between knowledge of antiretroviral therapy and stigma regarding adherence to ART among men who have sex with men. Enferm Clín. 2019;29:321-5. doi:https://doi.org/10.1016/j.enfcli.2019.06.004.

Clay PG, Yuet WC, Moecklinghoff CH, et al. A meta-analysis comparing 48-week treatment outcomes of single and multi-tablet antiretroviral regimens for the treatment of people living with HIV. AIDS Res Ther. 2018;15(1):17. doi:10.1186/s12981-018-0204-0.

Cardoso TS, Costa J de O, Reis EA, et al. Which antiretroviral regimen is associated with higher adherence in Brazil? A comparison of single, multi, and dolutegravir-based regimens. Cad Saude Publica. 2019;35(9):e00115518. doi:10.1590/0102-311X00115518.

Ndoro T, Ndlovu N, Nyasulu P. Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: a cross-sectional study. PLoS One. 2022;17(11):e0277039. doi:10.1371/journal.pone.0277039.

Gordillo V, del Amo J, Soriano V, González-Lahoz J. Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS. 1999;13(13):1763-9. doi:10.1097/00002030-199909100-00021.

Downloads

Published

21-06-2024

Issue

Section

ORIGINAL CLINICAL RESEARCH

How to Cite

1.
Muthmainnah, Katu S, Tabri NA, Syamsuddin S, Bakri S, Seweng A. Association between perceptions of antiretroviral drug use and medication adherence in patients with human immunodeficiency virus. Acta Biomed. 2024;95(3):e2024074. doi:10.23750/abm.v95i3.15619