Encephalitis in multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection: A case series
Keywords:
multisystem inflammatory disease, neurological involvement, children, SARS-CoV2Abstract
Backgroung and aim: Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV2 infection is a systemic hyper-inflammatory condition affecting children with a recent acute SARS-CoV2 infection. It is usually characterized by persistent fever, mucocutaneous involvement, lymphadenopathy, gastrointestinal symptoms, cardiac dysfunction. Neurological involvement in MIS-C is frequent but not clearly defined: patients may develop acute neurological involvement, characterized by rapid onset of focal neurological signs and electrical abnormalities.
Methods and results: Herein we report 3 cases of children with MIS-C developing an acute encephalopathy.
Conclusion: Additional data are needed in order to evaluate the prevalence of acute encephalitis in patients with MIS-C and characterize its presentation and define long-term outcomes.
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Copyright (c) 2025 Luca Bernardo, Marta Brambilla, Marco Ugo Sartorio, Martina Sandini, Francesca Casini, Clelia Di Mari, Angela Mauro
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