Comparative efficacy of low-dose versus high-dose inhaled nitric oxide in extreme preterm infants with hypoxic respiratory failure: A retrospective cohort study

Hamdy Alsayed Ali; Mohamad Rami Alturk; Salah Abumhara; Fadi  Alkhzzam

doi:10.23750/abm.v96i6.17006

Comparative efficacy of low-dose versus high-dose inhaled nitric oxide in extreme preterm infants with hypoxic respiratory failure: A retrospective cohort study

Authors

Hamdy Alsayed Ali Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation, Doha, Qatar
Mohamad Rami Alturk Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation, Doha, Qatar
Salah Abumhara Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation, Doha, Qatar
Fadi Alkhzzam Women’s Wellness and Research Center (WWRC), Hamad Medical Corporation, Doha, Qatar

Keywords:

persistent pulmonary hypertension of the newborn (PPHN), inhaled nitric oxide, preterm infants

References

1. Stritzke A, Bhandari V, Lodha A. Use of inhaled nitric oxide in preterm infants: Is there sufficient evidence? Indian J Pediatr. 2021;88(2):1-5. doi:10.1007/s12098-020-03493-6

2. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. The role of nitric oxide on endothelial function. Curr Vasc Pharmacol. 2012;10(1):4-18. doi:10.2174/157016112798829760

3. Askie LM, Ballard RA, Cutter GR, et al. Inhaled nitric oxide in preterm infants: an individual-patient data meta-analysis of randomized trials. Pediatrics. 2011;128(4):729-39. doi:10.1542/peds.2010-2722

4. Barrington KJ, Finer N, Pennaforte T. Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database Syst Rev. 2017;1(1) , doi:10.1002/14651858.CD000509.pub5

5. Ahluwalia J, Tooley J, Cheema I, et al. A dose-response study of inhaled nitric oxide in hypoxic respiratory failure in preterm infants. Early Hum Dev. 2006;82(7):477-83. doi:10.1016/j.earlhumdev.2005.12.003

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Published

15-12-2025

Issue

Vol. 96 No. 6 (2025)

Section

LETTERS TO THE EDITOR AND CORRESPONDENCE

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How to Cite

Alsayed Ali H, Alturk MR, Abumhara S, Alkhzzam F. Comparative efficacy of low-dose versus high-dose inhaled nitric oxide in extreme preterm infants with hypoxic respiratory failure: A retrospective cohort study. Acta Biomed. 2025;96(6):17006. doi:10.23750/abm.v96i6.17006

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