The Schmidt Syndrome

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Carmine Siniscalchi
Valentina Moretti
Simona Cataldo
Anna Rocci
Manuela Basaglia
Maria Ilaria Tassoni
Roberto Quintavalla


autoimmune polyendocrine syndrome, autoimmune Addison's disease, Schmidt syndrome


Addison’s disease (AD) is a rare endocrine condition related to adrenal insufficiency. Autoimmune adrenalitis is commonly associated with autoimmune diseases. Autoimmune Addison’s Disease (AAD) describes Autoimmune Polyendocrine Syndrome (APS) in 60% of patients with an important immunitary pathogenesis imprinting. We describes a case of Autoimmune Polyendocrine Syndrome charachterize by adrenal insufficiency and thyroid disease (Schmidt Syndrome). In this case report, Addison’s disease had a slow onset in absence of the typical weight loss. In our considerations this is due to the concomitant hypothyroidism that masked some typical signs and also limited acute presentation. 


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