Peculiarities of autoimmune polyglandular syndromes in children and adolescents

Peculiarities of autoimmune polyglandular syndromes in children and adolescents

Authors

  • Giuseppina Zirilli Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
  • Simona Santucci Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
  • Chiara Cuzzupè Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
  • Domenico Corica Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
  • Elda Pitrolo Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
  • Giuseppina Salzano Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy

Keywords:

Associations of autoimmune disorders, epidemiology, immunodeficiency, phenotypical expression

Abstract

Background: no reviews have specifically addressed , to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric age

Objectives: to review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescence

Design: the main features of the different APSs in pediatric age were compared among them.

Conclusions: 1) Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparathyroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications.

 

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Published

23-10-2017

How to Cite

1.
Zirilli G, Santucci S, Cuzzupè C, Corica D, Pitrolo E, Salzano G. Peculiarities of autoimmune polyglandular syndromes in children and adolescents. Acta Biomed [Internet]. 2017 Oct. 23 [cited 2024 Jul. 23];88(3):271-5. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/5898