Surgical treatment of multiple sporadic colorectal carcinoma.

Surgical treatment of multiple sporadic colorectal carcinoma.

Authors

  • Stefano Cecchini Dipartimento di Scienze Chirurgiche, sezione di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli studi di Parma, Via Gramsci n.14, 43100 Parma Italia.
  • Cinzia Azzoni
  • Lorena Bottarelli
  • Federico Marchesi Dipartimento di Scienze Chirurgiche, sezione di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli studi di Parma, Via Gramsci n.14, 43100 Parma Italia.
  • Francesco Rubichi
  • Enrico Maria Silini
  • Luigi Roncoroni

Keywords:

multiple colorectal cancer, synchronous colorectal cancer, metachronous colorectal cancer, subtotal colectomy, multiple segmental resections.

Abstract

Aim: Many aspects of the surgical management of multiple sporadic colorectal cancer syndrome, either synchronous and metachronous, remain to be cleared, in particular the prognostic influence of the extent of surgical resection. Method: A retrospective review was performed of patients diagnosed with multiple colorectal cancer from 1982 to May 2010. Clinical and pathologic data were collected and reviewed. Survival analysis was performed. Results: We identified 23 patients with multiple sporadic colorectal cancers, of which 8 had synchronous (SC) and 15 metachronous cancers (MC). Of the MC patients, 2 (13%) had the second cancer within 2 years, 4 (27%) in the time period of 2-5 years and 9 (60%) after 5 years. Twenty-one patients underwent multiple segmental resections; 2 patients underwent subtotal colectomy. The 5-year overall survival rate of SC and MC patients was 100% and 87% (p<0.001) respectively. The 5-year overall survival rate of multiple segmental resection patients and subtotal colectomy was 94% and 75% (p=0.655) respectively. Conclusion: Either synchronous and metachronous MSCRC patients showed good prognosis independently from to the extent of resection. Our results support a less aggressive biological behaviour allowing a more conservative management. Multiple segmental colorectal resections seem appropriate from an oncologic point of view in MSCRC patients. 

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Published

28-04-2017

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Section

ORIGINAL ARTICLES

How to Cite

1.
Cecchini S, Azzoni C, Bottarelli L, Marchesi F, Rubichi F, Silini EM, et al. Surgical treatment of multiple sporadic colorectal carcinoma. Acta Biomed [Internet]. 2017 Apr. 28 [cited 2024 Jul. 17];88(1):39-44. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/6031