Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure

Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure

Authors

  • Mohammad Jafar Mahmoudi
  • Mona Hedayat Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
  • Mohammad Taghvaei Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Sara Harsini Tehran University of Medical Sciences
  • Ebrahim Nematipour Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  • Nima Rezaei
  • Elham Farhadi Hematology Department, School of Allied Medical Science, Tehran University of Medical Sciences, Tehran, Iran; 7 School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  • Maryam Mahmoudi School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  • Maryam Sadr Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Nilufar Esfahanian Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Keramat Nourijelyani Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Ali Akbar Amirzargar Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Keywords:

Heart failure, Single nucleotide polymorphism, Interleukin-10, Transforming growth factor beta1

Abstract

Background: As cytokines, including interleukin-10 (IL-10) and transforming growth factor beta 1(TGF-β1) seem to contribute towards the pathogenesis of chronic heart failure (CHF), this study was performed to assess the associations of certain single nucleotide polymorphisms (SNPs) of these genes in a case control study. Methods: This investigation was carried out to determine the frequency of alleles, genotypes and haplotypes of TGF-β1 and IL-10 single-nucleotide polymorphisms (SNPs) in 57 Iranian patients with CHF compared with 140 healthy subjects using polymerase chain reaction with sequence-specific primers method. Results: Results of the analyzed data divulged a negative association for both TGF-β1 GC genotype at codon 25 (P=0.047) and CT genotype at codon 10 (P=0.018) and CHF proneness. Although, TGF-β1 CC genotype at codon 10 was found to be positively associated with CHF (P=0.011). Moreover, the frequency of IL-10 (−1082, -819, -592) ATA haplotype and TGF-β1 (codon 10, codon 25) TG haplotype were significantly lower in the patients group (P=0.004 and P=0.040, respectively), while TGF-β1 (codon 10, codon 25) CG haplotype was overrepresented in patients with CHF (P=0.007). Conclusions: Cytokine gene polymorphisms might affect vulnerability to CHF. Particular genotypes and haplotypes in IL-10 and TGF-β1 genes could render individuals more susceptible to CHF.

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Published

23-05-2019

Issue

Section

ORIGINAL ARTICLES

How to Cite

1.
Mahmoudi MJ, Hedayat M, Taghvaei M, Harsini S, Nematipour E, Rezaei N, et al. Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure. Acta Biomed [Internet]. 2019 May 23 [cited 2024 Jul. 16];90(2):221-7. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/6681