Chronic urticaria and drug hypersensitivity in children

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Carlo Mastrorilli
Roberto Bernardini
Lucia Liotti
Fabrizio Franceschini
Giuseppe Crisafulli
Silvia Caimmi
Paolo Bottau
Francesca Mori
Fabio Cardinale
Francesca Saretta
Giovanni Simeone
Marcello Bergamini
Carlo Caffarelli

Keywords

drug hypersensitivity reactions, children, urticaria, skin test, specific IgE, basophil activation test, drug provocation test

Abstract

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. The diagnostic work-up of chronic urticaria includes a comprehensive evaluation of triggering factors such as drugs. A diagnosis is necessary in order to permit a safely administration of drugs in children with chronic urticaria. 

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