Celiac disease and headache in children: a narrative state of the art: Celiac disease and headache

Celiac disease and headache in children: a narrative state of the art

Celiac disease and headache


  • Luca Sabino Pediatric and Pediatric Emergency Department, University Hospital “Policlinico-Vittorio Emanuele” and cPediatric Clinic, Department of Clinical and Experimental Medicine, University Hospital “Policlinico-Vittorio Emanuele”, Catania, Italy
  • Silvia Marino aPediatric and Pediatric Emergency Department, University Hospital “Policlinico-Vittorio Emanuele”, Catania, Italy;
  • Raffaele Falsaperla aPediatric and Pediatric Emergency Department, University Hospital “Policlinico-Vittorio Emanuele”, Catania, Italy
  • Francesco Pisani Child Neuropsychiatric Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy
  • Carmen Massimino cPediatric Clinic, Department of Clinical and Experimental Medicine, University Hospital “Policlinico-Vittorio Emanuele”, Catania, Italy
  • Piero Pavone Pediatric Clinic, Department of Clinical and Experimental Medicine, University Hospital “Policlinico-Vittorio Emanuele”, Catania, Italy


Celiac disease, childhood , headache, therapy


Celiac disease (CD) is one of the most important entity of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestation can be present either at the onset of CD, or appear during the development of the pathology, and different can be the neurologic findings. Clinical features are very variable, ranging from typical manifestations of gastrointestinal involvement to neurologic symptom. The most frequent neurologic signs reported were headache, epileptic seizure, migraine, mental retardation, ataxia and attention deficit and hyperactive disorder. Headache either in form of migraine, or in non-specific form represents one of the main clinical presentation in CD. The aim of this work is to provide a narrative review of the pediatric literature focused on the cephalalgic features of children with CD evaluating the potential benefits of a gluten free diet (GFD).  Papers were identified by searching for related literature in Medline (PubMed) and Embase using the words “Celiac Disease” and “Headache” or “Migraine” by specifying “children”/“paediatric age” for reports published since 1972 till 31th October 2018. According to our inclusion criteria, a total of 25 papers has been evaluated. Although it is still controversial if headache is prevalent in CD children a correct compliance to a GFD seems to improve the neurological symptoms even if the underlying pathogenic relationship between CD and neurologic system involvement is still not fully understood.


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How to Cite

Sabino L, Marino S, Falsaperla R, Pisani F, Massimino C, Pavone P. Celiac disease and headache in children: a narrative state of the art: Celiac disease and headache. Acta Biomed [Internet]. 2020 Sep. 7 [cited 2024 Jul. 12];91(3):e2020056. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8224