Diagnostic value/performance of radiological liver imaging during chemoterapy for gastrointestinal malignancy: a critical review

Diagnostic value/performance of radiological liver imaging during chemoterapy for gastrointestinal malignancy: a critical review

Authors

  • Alfonso Reginelli Department of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, Italy
  • Giovanna Vacca Department of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, Italy
  • Nicoletta Zanaletti Medical Oncology, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Teresa Troiani Medical Oncology, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Raffaele Natella Department of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, Italy
  • Nicola Maggialetti Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, Italy
  • Pierpaolo Palumbo Department of Biotechnology and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Andrea Giovagnoni Department of Radiology, Università Politecnica delle Marche, Ancona, Italy
  • Fortunato Ciardiello Medical Oncology, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Salvatore Cappabianca Department of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, Italy

Keywords:

colorectal cancer-chemotherapy-induced focal hepatopathy, steatosis, steatohepatitis, sinusoidal obstruction syndrome, liver MR - hepatobiliary phase-Liver CT

Abstract

This article reviews the main toxic effect, complications and relative imaging findings of the liver that may appear during the oncologic follow up among patients affected by gastrointestinal malignancy. Awareness of the causative chemotherapeutic agent and regimens, pathophysiology and relative characteristic imaging findings of hepatic injuries is critical in order to obtain an accurate diagnosis especially when these parenchymal lesions are focal. An accurate synergic radiological diagnosis with Computed Tomography (CT) and Magnetic Resonance (MR) techniques may induce a potential termination of ineffective/toxic chemotherapy during early phases of treatment, changing the therapeutic plan in order to avoid first unnecessary liver biopsy and then invasive treatment as hepatic resection if not required.

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Published

24-04-2019

How to Cite

1.
Reginelli A, Vacca G, Zanaletti N, Troiani T, Natella R, Maggialetti N, et al. Diagnostic value/performance of radiological liver imaging during chemoterapy for gastrointestinal malignancy: a critical review. Acta Biomed [Internet]. 2019 Apr. 24 [cited 2024 Jul. 22];90(5-S):51-6. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8346