Metformin, arterial contrast and acute kidney Injury

Metformin, arterial contrast and acute kidney Injury

Authors

  • Amos Lal Saint Vincent Hospital, Worcester, MA https://orcid.org/0000-0002-0021-2033
  • Nimal Kaur Saint Vincent Hospital, Worcester MA
  • Nitin Trivedi 1. University of Massachusetts Medical School, Worcester Massachusetts; 2. Saint Vincent Hospital, Worcester Massachusetts, USA

Keywords:

Metformin, Contrast induced nephropathy, Acute Kidney Injury, Coronary angiography, Diabetes Mellitus

Abstract

Background and aim of the work: We aim to respond to interesting article in your journal by Namazi et al. regarding metformin use in patients undergoing coronary angiography and risk of developing metformin associated lactic acidosis. We share our experience regarding patients using metformin undergoing urgent coronary angiography and risk of developing contrast induced nephropathy.

Methods: A retrospective chart review of 154 patients who underwent emergency coronary angiography (CAG) with arterial contrast exposure. The study was approved by the institution review board (Metrowest Medical Center IRB, Framingham Massachusetts, USA).

Results: 154 patients admitted with acute coronary syndrome during months of January 2014 – December 2014; 67 patients used metformin (100% had diabetes mellitus) whereas 87 were not on metformin (31% had diabetes mellitus). Our study revealed no difference in contrast induced nephropathy (CIN) between the two groups (p=0.29), when compared at 48 hours after arterial contrast exposure. Higher serum creatinine may be have precluded the use of metformin in the control group.

Conclusions: Our single center, small observational study showed no difference in the incidence of CIN in patients who continued to be on metformin after arterial contrast exposure compared to the control group

Author Biographies

Amos Lal, Saint Vincent Hospital, Worcester, MA

Department of Internal Medicine

123 Summer Street

Saint Vincent Hospital, Worcester, Massachusetts. USA 01608

Phone: 5083635000

Email: [email protected]; [email protected]

ORCID ID: 0000-0002-0021-2033

 

Nimal Kaur, Saint Vincent Hospital, Worcester MA

Fellow in Cardio-Vascular Medicine, Saint Vincent Hospital, Worcester MA

Nitin Trivedi, 1. University of Massachusetts Medical School, Worcester Massachusetts; 2. Saint Vincent Hospital, Worcester Massachusetts, USA

Nitin Trivedi, MD, FACP, FACE

Director, Division of Endocrinology

Associate Program Director, Internal Medicine Residency

Department of Medicine, Saint Vincent Hospital

Associate Professor of Medicine

University of Massachusetts Medical School

123 Summer Street

Saint Vincent Hospital, Worcester, Massachusetts. USA 01608

Phone: 508-363-5000

E-mail:  [email protected]

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Published

23-05-2019

Issue

Section

E-LETTERS: COMMENTS AND RESPONSES

How to Cite

1.
Lal A, Kaur N, Trivedi N. Metformin, arterial contrast and acute kidney Injury. Acta Biomed [Internet]. 2019 May 23 [cited 2024 Jul. 20];90(2):355-6. Available from: https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/8371